Multi-region and potential test sensors, methods, and systems
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A sensor, potential technology, applied in the field of multi-zone and potential test sensors, and systems, can solve problems such as trouble, chemical pollution, etc.
Active Publication Date: 2010-09-29
ASCENSIA DIABETES CARE HLDG AG
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A disadvantage common to these systems is the single sample chamber where adjacent electrode systems / detection areas may chemically contaminate each other due to diffusion and / or liquid movement
This disadvantage is especially troublesome when one reagent system requires a longer assay time than the other and / or when the test sensor is mechanically disturbed after filling the sample
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[0058] The present invention discloses a biosensor system comprising a test sensor having at least three independently addressable analysis regions. Each analysis region includes conductors or electrodes and can be substantially chemically isolated. Thus, the working electrode and the counter electrode of the electrode pair may exist in a substantially chemically isolated environment. A working electrode can be combined with two or more counter electrodes, where each counter electrode exists in a substantially chemically isolated environment. Thus, the system may comprise at least two counter electrodes operating at different potentials. Independent addressability of substantially chemically isolated analysis regions provides for multipotential electrochemical analysis.
[0059] By working at more than one potential, samples including multiple analytes can be analyzed. Multiple independent analyzes of the same analyte can be performed to increase the accuracy and / or precisi...
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Abstract
Biosensor systems including a measurement device and test sensors including at least three independently addressable electrodes, with at least two of the electrodes being substantially chemically isolated are disclosed. One or more working electrodes may be combined with two or more counter electrodes. The two or more counter electrodes may operate at different potentials to provide for multi-analyte electrochemical analysis. Analysis methods are provided to perform multi-analyte electrochemical analysis and test sensors are provided having resistance to chemical mixing between secondary analysis regions.
Description
[0001] Cross References to Related Documents [0002] This application claims priority to US Provisional Application No. 60 / 974,823, filed September 24, 2007, entitled "Multipotential Biosensors, Systems, and Methods," the entire contents of which are incorporated herein by reference. Background technique [0003] Biosensors provide analysis of biological fluids such as whole blood, serum, plasma, urine, saliva, interstitial or intracellular fluid, and the like. Typically, a biosensor has a measuring device that analyzes a sample present in the test sensor. The sample is usually in liquid form and may not only be a biological fluid but also a derivative of a biological fluid such as an extract, dilution, filtrate or regenerated deposit. Analysis by the biosensor determines the presence and / or concentration of one or more analytes such as alcohol, glucose, uric acid, lactic acid species, cholesterol, bilirubin, free fatty acids, glycerol in biological fluids Triesters, protei...
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