Compound preparation used for treating melancholia and senile dementia

Abstract

The invention discloses a compound preparation used for treating depression and senile dementia. The compound preparation comprises the following components in part by weight: 1 part of rolipram and 0.25 to 200 parts of antiemetic medicament, wherein the antiemetic medicament is granisetron, ondansetron, tropisetron, aprepitant or metoclopramide. The compound preparation is prepared from the rolipram and the granisetron, the ondansetron, the tropisetron, the aprepitant or the metoclopramide. The compound preparation has an effective curative effect of treating the melancholia and the senile dementia, and simultaneously solves the technical problems that in the prior art, the rolipram causes adverse reactions such as vomition, sicchasia, headache and the like.

Description

technical field [0001] The invention relates to a medicament, specifically a compound preparation for treating depression and senile dementia. Background technique [0002] In the past two decades, with the deepening of understanding of rolipram and phosphodiesterase 4 (PDE4), PDE4 inhibitors are not only limited to the potential of central nervous system diseases, but also have anti-inflammatory effects such as asthma, COPD ( Chronic obstructive pulmonary disease), rheumatoid arthritis and other inflammatory disease animal models also have good results. Therefore, it is particularly important to develop new PDE4 inhibitors and reduce the adverse reactions of such inhibitors. Rolipram, a classic inhibitor of phosphodiesterase 4 (PDE4), was once marketed as an antidepressant drug, comparable to the classic tricyclic antidepressant drug amitriptyline, but it was blocked due to adverse reactions such as vomiting, nausea, and headache. Clinical application. The specific mecha...

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Problems solved by technology

[0003] The technical problem to be solved by this invention is to provide a compound preparation for the treatment of depression and senile dementia for the above-mentioned current state of the art, which has an effective therapeutic effect on depression and senile dementia, and solves the problems of the prior art at the same time. Technical problems of rolipram causing adverse reactions such as vomiting, nausea, and headache

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