Huperzine-A solid dispersion and method for preparing tablet thereof

Abstract

The invention discloses a huperzine-A solid dispersion and a method for preparing a tablet thereof. The huperzine-A solid dispersion comprises huperzine-A and a carrier used as a dispersant; the weight ratio range of the carrier to the huperzine-A is 1-25:1; the carrier material may be one or more of polyvinylpyrrolidone, polyethylene glycol 4000, polyethylene glycol 6000, Poloxamer 188, mannitol, lactose or microcrystalline cellulose; and the huperzine-A solid dispersion is prepared by adopting a grinding method, and the obtained solid dispersion can be prepared into huperzine-A tablets by adopting a wet granulating and tabletting method. The huperzine-A solid dispersion can remarkably increase the solubility of a medicament and promote the absorption so as to greatly improve the dissolution and bioavailability of the medicament.

Description

technical field

[0001] The invention relates to the technical field of medicines, in particular to a huperzine A solid dispersion capable of improving the dissolution rate and bioavailability of medicines and a method for preparing tablets thereof. Background technique

[0002] Huperzine A chemical name: (5R,9R,11E)-5-amino-11-ethylene-5,8,9,10-tetrahydro-7-methyl-5,9-methylenecyclooctyl Tetraeno[b]pyridin-2(1H)-ones.

[0003] Molecular formula: C 15 h 18 N 2 O molecular weight: 242.32

[0004] Huperzine A Tablet is suitable for benign memory disorders, improving the ability of patients to point to memory, associative learning, image recall, meaningless graphic recognition and portrait recall. It can also improve memory impairment caused by dementia patients and brain organic diseases.

[0005] Pharmacology and Toxicology: Huperzine A Tablet is a cholinesterase inhibitor, which has a selective inhibitory effect on true ChE and can easily pass through the blood-brain ba...