Injection molding process of plastic microfluidic chip

An injection molding process and microfluidic chip technology, applied in laboratory containers, laboratory utensils, chemical/physical/physicochemical processes, etc., to solve the problem of incomplete replication of microchannels, promote applications, and improve manufacturing levels Effect

Inactive Publication Date: 2010-10-20
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention proposes an injection molding process for plastic microfluidic chips, which solves the problem of molding plastic microfluidic chips with a microchannel width of 30-100 μm

Method used

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  • Injection molding process of plastic microfluidic chip
  • Injection molding process of plastic microfluidic chip
  • Injection molding process of plastic microfluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Single cross microfluidic chip, the product is 80mm long, 30mm wide, and 1.2mm thick, with 2 cavities in one mold, the cross-sectional depth of the microchannel is 50μm, and the width is 70μm. The material is PMMA.

[0021] (A) Put the dried PMMA into the hopper of the injection molding machine, set the temperature of the barrel: 230°C for the nozzle, 250°C for the first zone, 245°C for the second zone, and 220°C for the third zone;

[0022] (B) The mold temperature is set to 89°C;

[0023] (C) The mold is closed and enters the injection stage. The injection pressure is: 100MPa for the first stage, 110MPa for the second stage, and 110MPa for the third stage. The injection time is 2.6s. The injection speed adopts the form of slow-fast-slow. The injection speed is set as: the first stage 90mm / s, the second section 140mm / s, the third section 60mm / s;

[0024] (D) Entering the pressure-holding stage, the pressure-holding pressure is 70MPa, and the pressure-holding time is 4...

Embodiment 2

[0029] Double cross microfluidic chip (two cross microchannels on each chip), the product is 62mm long, 60mm wide, and 1.2mm thick, with 2 cavities in one mold, the cross-sectional depth of the microchannel is 50μm, and the width is 50μm. The material is PMMA.

[0030] (G) Put the dried PMMA into the hopper of the injection molding machine, set the temperature of the barrel: 230°C for the nozzle, 250°C for the first zone, 245°C for the second zone, and 220°C for the third zone;

[0031] (H) mold temperature is set to 89 ℃;

[0032] (1) The mold is closed and enters the injection stage. The injection pressure is: 100MPa for the first stage, 110MPa for the second stage, and 120MPa for the third stage. The injection time is 2.6s. The injection speed adopts the form of slow-fast-slow, and the injection speed is set as: the first stage 90mm / s, the second section 140mm / s, the third section 60mm / s;

[0033] (J) Enter the pressure-holding stage, the pressure-holding pressure is 70MPa...

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Abstract

The invention discloses a microfluidic chip injection molding process capable forming a micro-channel structure on the surface, which belongs to the technical field of injection molding. The appearance of the formed microfluidic chip is in a plate structure, and the thickness thereof is generally 1.2 to 1.5mm; the chip is provided with the crisscross micro-channel, and the cross section thereof is a rectangle with the depth of about 50mu m and the width between 30 to 100mu m. PMMA raw material is selected, the mold temperature is 85 to 90DEG C, and the melt temperature is 230 to 250DEG C. The injection speed is in a control method of slow-quick-slow, wherein the speed of a high-speed section of about 140mm/s. The injection pressure is 100 to 130MPa, the holding pressure is 50 to 70MPa, the holding time is 2 to 5s, and the cooling time is 30 to 40s. After cooling, the mold is opened, a product is taken out to complete the whole forming process. The invention has the beneficial effects that the injection forming process can form plastic microfluidic chips with high efficiency in a large scale, effectively solves the technical difficult problems of incomplete replication of the micro-channel and the like during the forming process, and promotes the application of an injection molding technology in the micro-mechanical system field.

Description

technical field [0001] The invention belongs to the technical field of injection molding, and relates to an injection molding process of a microfluidic chip capable of forming a microchannel structure on the surface. Background technique [0002] Microfluidic chip, also known as lab-on-a-chip, its function is to integrate the basic operation units such as sample preparation, reaction, separation and detection involved in the fields of biology and chemistry into a chip of tens of square centimeters (or even smaller) On the surface, a network is formed by microchannels, and controllable fluids run through the entire system to replace various functions of conventional biological or chemical laboratories, and are widely used in biochemistry, clinical, pharmaceutical and environmental fields. Traditional materials used to form microfluidic chips include silicon, glass and quartz, etc., which are mainly processed by etching. In recent years, due to the advantages of low cost, var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C45/00B29C45/27B01J19/00B01L3/00
Inventor 宋满仓刘莹庞中华王敏杰刘冲
Owner DALIAN UNIV OF TECH
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