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Surface plasmon resonance imaging sensing system

A surface plasmon and resonance imaging technology, which is applied in the field of biochemical substance detection systems, can solve problems such as measurement errors and interference measurement results, and achieve the effects of improving detection throughput and imaging signal-to-noise ratio, avoiding speckle phenomenon, and stable performance

Inactive Publication Date: 2010-10-20
SHENZHEN INT TRAVEL HEALTHCARE CENT +1
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Problems solved by technology

However, the above patents all use laser or laser diode coherent light as the SPR light source, and coherent light or partially coherent light is prone to laser speckle, which interferes with the measurement results
Especially in SPR imaging technology, the influence of laser speckle caused by coherent light or partially coherent light is more serious, which can cause measurement errors in severe cases

Method used

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Embodiment Construction

[0015] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0016] Such as figure 1 As shown, the present invention includes a surface plasmon resonator 1, an incoherent light source 2, a beam shaper 3, a polarizer 4, a narrowband filter 5, an analyzer 6, an imaging lens group 7 and A side array photoelectric sensor 8. Wherein, the surface plasmon resonator 1 is a prism, and its cross section is an isosceles triangle, the surface where the base of the isosceles triangle is located is the bottom surface A, and the surfaces where the two waists of the isosceles triangle are located are the isosceles sides B, C. A metal reflective film is coated on the bottom surface A of the surface plasmon resonator 1 as the sensing plane 11 of the present invention. The metal reflective film can be a gold film or a silver film, and its thickness can be selected within the range of 35nm-55nm. In this embodiment, a gold film...

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Abstract

The invention relates to a surface plasmon resonance imaging sensing system, which comprises a plasma resonator with isosceles triangle cross-section, wherein the plane of the bottom side of the isosceles triangle is of a sensing plane, and a layer of metal reflection film is plated on the sensing plane; a sample pool with an inlet and an outlet is arranged on the metal reflection film, and one of the planes of the two sides of equal length is used as an incident plane, and the other thereof is used as an emittance plane; a power source, a beam shaper and a polarizer are sequentially arranged on an incident light path which is vertical to the incident plane to reach the sensing plane, and an analyzer, an imaging lens group and an area array photoelectric sensor are sequentially arranged on a reflection light path generated by the sensing plane; and the area array photoelectric sensor is positioned on a focal plane of the imaging lens group and is connected with an external computer. The surface plasmon resonance imaging sensing system is characterized in that: the light source is a non-coherent light source, and a narrow-band filter is arranged between the polarizer and the incident surface. The invention can be widely used in food safety detection, pesticide residue detection, bio-molecule detection, bio-terrorist detection and other fields.

Description

technical field [0001] The invention relates to a biochemical substance detection system, in particular to a high-throughput surface plasmon resonance imaging sensing system. Background technique [0002] Surface plasmon resonance (Surface P1asmon Resonance, SPR) was discovered by Wood at the beginning of last century. In the 1960s, German scientists Otto and Kretchmann independently invented the method of exciting surface plasmons with visible light. In the 1980s, Swedish scientist Liedberg used this technology for the detection of biomacromolecular interactions. SPR technology uses the principle that the incident light can excite the surface plasmon wave (Surface Plasmon Wave, SPW) at the interface between the medium and the metal under certain conditions, thereby causing a significant decrease in the energy of the reflected light. Due to the advantages of high sensitivity, high precision, easy implementation of specific detection and strong real-time performance, SPR te...

Claims

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Application Information

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IPC IPC(8): G01N21/41G01N21/01
Inventor 顾大勇邵永红刘春晓史蕾赵纯中杨燕秋徐云庆李政良黄彤文李震李长春滕娟季明辉张威庄卫东
Owner SHENZHEN INT TRAVEL HEALTHCARE CENT
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