Stable, synergistic mixtures

A composition, methyl technology, applied in the direction of animal repellent, plant growth regulator, botanical equipment and methods, etc., can solve the problem of not fully showing activity, low storage stability, limiting industrial applicability, etc. problems, to achieve a reduced potential for skin sensitization

Inactive Publication Date: 2010-10-20
LANXESS DEUTDCHLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the mixtures of the above-mentioned prior art are all characterized in that their storage stability is very low due to the formation of degradation products, which greatly limits their industrial applicability, or they do not fully show the desired activity

Method used

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  • Stable, synergistic mixtures
  • Stable, synergistic mixtures
  • Stable, synergistic mixtures

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0071] Different concentrations of GDA and MIT and mixtures of these two active substances were tested against the bacterium Pseudomonas fluorescens. Cultivation was performed in Landy's minimal medium at pH 7 and 26°C. The growth of Pseudomonas fluorescens at different active substance concentrations was compared with the growth without active substance. The lowest concentration at which growth is no longer detectable is called the minimum inhibitory concentration (MIC).

[0072] active substance

[0073] active substance

[0074] The determined index data show that the combination of GDA and MIT according to the invention shows a particularly pronounced synergistic effect.

example 2

[0076] Different concentrations of GDA and MIT and mixtures of these two active substances were tested against the bacterium Pseudomonas fluorescens. Cultivation was performed in Landy's minimal medium at pH 9 and 26°C. The growth of Pseudomonas fluorescens at these different active substance concentrations was compared with the growth in the absence of active substance. The lowest concentration at which growth was no longer detectable was called the minimum inhibitory concentration (MIC).

[0077] active substance

[0078] The determined index data show that the combination of GDA and MIT according to the invention shows a particularly pronounced synergistic effect.

example 3

[0080] Different concentrations of GDA and MIT and mixtures of these two active substances were tested against the bacterium Corynebacterium. The cultivation was carried out in Landy's minimal medium at pH 9 and 26°C. The growth of the coryneform bacteria at these different active substance concentrations was compared with the growth in the absence of active substance. The lowest concentration at which growth was no longer detectable was called the minimum inhibitory concentration (MIC).

[0081] active substance

[0082] active substance

[0083] The determined index data show that the combination of GDA and MIT according to the invention shows a particularly pronounced synergistic effect.

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Abstract

The present invention relates to storage-stable, synergistically acting combinations comprising glutaraldehyde (GDA) and 2-methyl-2H-isothiazol-3-one (methylisothiazolinone, MIT) and, where appropriate, 2-bromo-2-nitropropane-1,3-diol (bronopol) and / or other active substances for protecting industrial materials.

Description

technical field [0001] The present invention relates to storage-stable, synergistic combinations comprising glutaraldehyde (GDA) and 2-methyl-2H-isothiazol-3-one (methylisothiazolinone, MIT) and, where appropriate , 2-bromo-2-nitropropane-1,3-diol (bronopol) and / or other active substances for the protection of industrial materials. Background technique [0002] As early as the 1960s, GDA was known as an antimicrobial active compound (Gorman, S.P., Scott, E.M. and Russel, A.D., 1980: Antimicrobial activity, uses and mechanism of action of glutaraldehyde. J. Appl. Bacteriol. 48, 161-90. ). Typically, GDA is used as a solution at a concentration of 2% to 50% by weight, the pH of the solution being <7. At pH values ​​greater than 7, GDA gradually tends to aggregate and also exhibits what is known as a "rapid kill" effect, which is why GDA is frequently used as a disinfectant and bactericide or also as a slimeicide, And to some extent less used as a preservative. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/80A01N31/02A01P1/00
CPCA01N43/80A01N35/02A01N35/08A01N2300/00
Inventor 赫尔曼·乌尔彼得·瓦赫特勒坦贾·格哈茨马丁·库格勒
Owner LANXESS DEUTDCHLAND GMBH
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