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Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit

A detection tool and technology for premature rupture of membranes, which are applied in the directions of measuring devices, instruments, disease diagnosis, etc., can solve problems such as detection tools for premature rupture of membranes that have not yet been found, and achieve a convenient industrial production, improved detection speed, and easy processing. Effect

Inactive Publication Date: 2015-01-07
ORIGISSAY BIOLOGICS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although in the third trimester of pregnancy (gestational weeks 28-40), ICAM-1 levels in amniotic fluid of pregnant women increase due to the expression of ICAM-1 on monocytes in the fetal membranes and amniotic fluid and the activation of neutrophils, but currently There are no reports of premature rupture of membranes detection tool using ICAM-1 as the detection index

Method used

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  • Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit
  • Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit
  • Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] In this embodiment, the rapid detection tool for premature rupture of membranes with ICAM-1 as the detection index is as follows: figure 1 , figure 2 As shown, its shape is a rectangular strip, and its structure includes a liner 1, an absorbent pad 2, a nitrocellulose membrane 5, a gold standard pad 6, and a sample pad 7, and the absorbent pad, nitrocellulose membrane, gold standard pad, and sample The pads are pasted on the liner sequentially from top to bottom, and the gold standard pad is partially covered by the sample pad. Liner 1 is made of medical plastic high-whiteness PVC sheet, coated with pressure-sensitive adhesive, which is inert to biologically active molecules; water-absorbing pad 2 is made of water-absorbing paper; 1 The detection line 4 formed by polyclonal antibody coating and the control line 3 formed by the goat anti-mouse IgG polyclonal antibody coating, the detection line 4 is located below the control line 3, and their width is 1mm (or 0.8mm or ...

Embodiment 2

[0053] In this embodiment, the shape and structure of the premature rupture of membranes rapid detection box with ICAM-1 as the detection index are as follows: Figure 6 As shown, it is composed of a box body 8 and a detection tool 12 loaded into the box body. The detection tool 12 is the detection tool with the shape and structure described in Embodiment 1. Described box body 8 is made of medical plastics, as image 3 , Figure 4 , Figure 5 As shown, the shape is a cuboid, and the inner cavity matches the shape and size of the testing tool. Its top wall is provided with a testing tool insertion hole 11, and its side wall is provided with a sampling hole 10 and an observation hole 9. The sampling hole 10 The setting position of the detection tool corresponds to the position of the sample pad 7 after the detection tool is loaded into the box body, and the setting position of the observation hole 9 corresponds to the position of the detection line 4 and the control line 3 af...

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Abstract

The present invention provides a rapid detection tool for premature rupture of fetal membrane taking inter-cellular adhesion molecule 1 (ICAM-1) as detection index, which comprises: a lining (1), a water absorbing pad (2), a nitrocellulose membrane (5), a gold-labeled pad (6) and a sample pad (7), said water absorbing pad (2), nitrocellulose membrane (5), gold-labeled pad (6) and sample pad (7) are orderly connected from the top to the bottom and bound to the lining(1), and the gold-labeled pad (6) is partly covered by the sample pad (7). A detection line (4) formed by the enveloping of sheep anti-human ICAM-1 polyclonal antibody and a control line (3) formed by the enveloping of sheep anti-mouse immunoglobulin G polyclonal antibody are disposed on the nitrocellulose membrane (5), wherein the detection line (4) is located below the control line (3). The gold-labeled pad (6) is water absorbing fibers enveloped with a gold-labeled mouse anti-human ICAM-1 monoclonal antibody conjugate. The present invention also provides a rapid detection kit for premature rupture of fetal membrane taking ICAM-1 as detection index.

Description

technical field [0001] The invention belongs to medical detection tools, in particular to a detection tool for detecting premature rupture of membranes (Premature Rupture of Fetal Membrane, PROM for short) in pregnant women. Background technique [0002] Rupture of Fetal Membrane (ROM) may occur at any time during pregnancy, and rupture of fetal membranes before labor is called premature rupture of membranes (PROM). The incidence of PROM after term (37 weeks of pregnancy) is about 10%; the incidence of PROM before term (before 37 weeks of pregnancy) is 2-3.5%. Premature rupture of membranes is the main factor causing prenatal and postpartum complications in obstetric patients, and the main reason for premature birth and neonatal admission to the intensive care unit. Because medical personnel have to balance the prolongation of gestational weeks with the risk of intrauterine and maternal infection and fetal lung development problems, the management of patients with premature...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/577G01N33/558G01N33/531
CPCG01N2333/70525G01N2800/368G01N33/689
Inventor 胡怀忠关祥乾向洪发周容
Owner ORIGISSAY BIOLOGICS TECH