Polymer capable of performing addition reaction with thiol and having stable bonding hydrolysis

Abstract

The invention discloses a polymer which can perform addition reaction with thiol and has stable hydrolysis. The polymer is formed by introducing at least one functional group shown in a formula (I) to a chain side and / or a chain end of a hydrophilic polymer, wherein X is any group or polymer chain. The polymer has the advantages that: the polymer can react with proteins or polypeptides under physiological environment without other micromolecule components, so the probably brought biotoxicity is avoided and the proteins to be modified are not influenced; and ester bonds, amido bonds, amido ester bonds and other easily hydrolytic chemical bonds are absent between the chemical bond formed after the addition reaction and a main chain, so the hydrolysis is stable.

Description

technical field The invention relates to a macromolecule capable of addition reaction with sulfhydryl groups and stable in bond hydrolysis. Background technique Protein and polypeptide drugs have become a research hotspot in recent years due to their specific effects and high efficiency. However, these drugs have problems such as poor stability, short plasma half-life and immunogenicity, which limit their application development. Since the 1970s, people began to use polymers (especially polyethylene glycol, PEG) to modify proteins and polypeptide molecules, so that the above problems were solved or alleviated. Today, this macromolecular modification technology has not only been widely used in the development of protein drugs, but also extended to various fields such as new drug carriers and controlled release preparations. In order to bind macromolecules (such as PEG) to proteins (or polypeptides), it is necessary to properly modify the macromolecules to have active groups ...

AI Technical Summary

Problems solved by technology

However, the introduction process of vinylsulfone group is cumbersome, and the production and synthesis process is easy to introduce toxic small molecules, so the current application range is still very limited

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