Method for preparing parabromo-phenetole
A technology of bromophenethyl ether and p-bromophenol, applied in the field of organic compound preparation, can solve problems such as low production efficiency, long production time, and many production equipment, and achieve the advantages of improving market competitiveness, avoiding equipment investment, and reducing production costs. Effect
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Embodiment 1
[0015] A preparation method of p-bromophenetole, comprising the following steps:
[0016] (1) Etherification reaction step: in a 50-liter reaction kettle with a heating device, electric stirring, and a thermometer, 10 moles of p-bromophenol, 200 moles of water, and 6.5 moles of diethyl sulfate are successively dropped into, and heated to 55 React at ±2°C, keep this temperature, add 11 moles of sodium hydroxide continuously, keep the reaction for 1 hour after adding sodium hydroxide, stop heating, and the etherification reaction is terminated.
[0017] (2) Water washing step: put 1000 moles of water into the mixed solution obtained after the etherification reaction, stir evenly, leave to stand for stratification, and separate the oil layer.
[0018] (3) Distillation step: the oil layer is distilled to obtain p-bromophenetole product, the content of the bromophenetole product is 96.5%, and the color is less than No. 50 (platinum-cobalt colorimetric).
Embodiment 2
[0020] A preparation method of p-bromophenetole, comprising the following steps:
[0021] (1) Etherification reaction step: drop into 10 moles of p-bromophenol successively, 200 moles of water, 6.5 moles of diethyl sulfate in a 50-liter reaction kettle with a heating device, electric stirring, and a thermometer, and heat to 70 moles while stirring. React at ±2°C, keep this temperature, add 11 moles of sodium hydroxide continuously, keep the reaction for 1 hour after adding sodium hydroxide, stop heating, and the etherification reaction is terminated.
[0022] (2) Water washing step: put 1000 moles of water into the mixed solution obtained after the etherification reaction, stir evenly, leave to stand for stratification, and separate the oil layer.
[0023] (3) Distillation step: the oil layer is distilled to obtain p-bromophenetole product, the content of the bromophenetole product is 96.5%, and the color is less than No. 50 (platinum-cobalt colorimetric).
Embodiment 3
[0025] A preparation method of p-bromophenetole, comprising the following steps:
[0026] (1) Etherification reaction step: drop into 10 moles of p-bromophenol successively, 200 moles of water, 6.5 moles of diethyl sulfate in a 50-liter reaction kettle with a heating device, electric stirring, and a thermometer, and heat to 80 moles simultaneously under stirring. React at ±2°C, keep this temperature, add 11 moles of sodium hydroxide continuously, keep the reaction for 1 hour after adding sodium hydroxide, stop heating, and the etherification reaction is terminated.
[0027] (2) Water washing step: put 1000 moles of water into the mixed solution obtained after the etherification reaction, stir evenly, leave to stand for stratification, and separate the oil layer.
[0028] (3) Distillation step: the oil layer is distilled to obtain p-bromophenetole product, the content of the bromophenetole product is 96.5%, and the color is less than No. 50 (platinum-cobalt colorimetric).
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