Medical application of 6-shogaol for preventing and curing radiation injury

A technology of radiation damage and shogaol, which is applied in the direction of drug combination, anti-toxic agent, ketone active ingredients, etc., and can solve the problems that the prevention and treatment of 6-shogaol have not yet been reported in relevant literature.

Inactive Publication Date: 2010-12-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the antioxidant activity of 6-shogaol has been widely concerned and applied. For example, Kikuzaki et al. confirmed that gingerols and diphenylheptane compounds isolated from ginger have certain antioxidant effects [Kikuzaki H ., Kobayashi M., Nakatani N.Phytochemistry, 1991, 30 (11): 3647-3651. Kikuzaki H., Nakatani N. Phytochemistry, 1996, 43 (1): 273-277.], but 6-shogaol The prevention and treatment of radiation injury has not been reported in the relevant literature

Method used

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  • Medical application of 6-shogaol for preventing and curing radiation injury
  • Medical application of 6-shogaol for preventing and curing radiation injury
  • Medical application of 6-shogaol for preventing and curing radiation injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Mice

[0015] 140 SPF grade male Kunming mice aged 6-8W, weighing 20±2g, were raised in the SPF grade experimental animal center.

[0016] 2. Experimental grouping (7 groups in total): 20 animals in each group, 140 animals in total.

[0017] (1) Normal control group: no radiation and 6S treatment.

[0018] (2) Radiation damage group: with 4Gy 60 Mice were irradiated with Coγ-rays.

[0019] (3) Positive drug group: intramuscular injection of 50 mg / kg estriol into mice on the day after irradiation.

[0020] (4) Low-dose 6S prevention group: 25 mg / kg / d 6G was orally administered to mice 5 days before irradiation.

[0021] (5) Low-dose 6S treatment group: On the day after irradiation, 25 mg / kg / d of 6G was orally administered to mice.

[0022] (6) Medium-dose 6S treatment group: On the day after irradiation, 50 mg / kg / d of 6G was orally administered to mice.

[0023] (7) High-dose 6S treatment group: On the day after irradiation, 100 mg / kg / d of 6G was orally administ...

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Abstract

The invention relates to the field of natural medicines, particularly to application of 6-shogaol for preventing and curing radiation injury. Pharmacological test proves that the 6-shogaol can effectively cure and prevent the radiation injury.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to the use of 6-shogaol in preventing and treating radiation damage. Background technique [0002] With the rapid development of the application of nuclear technology and the increasing damage of the protective layer of the atmospheric environment by industrial pollution, people have more and more opportunities to be exposed to radiation, and the possibility of suffering from ionizing radiation or radiation damage increases, and the body suffers from abnormal damage. At present, ionizing radiation damage mainly includes the effects on the hematopoietic function of the blood system, immune function, free radical production and cellular DNA damage. With the prolongation of the exposure time, various lesions will appear. And restore the hematopoietic function system, promote DNA damage repair, and greatly reduce the damage caused by radiation. At present, domestic prevention and treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P39/00
Inventor 李萍彭咏波马江周萍闻晓东刘鄂湖齐炼文陈君
Owner CHINA PHARM UNIV
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