Medicinal composition with anti-inflammatory and analgesic effect and preparation method and application thereof

An anti-inflammatory and analgesic composition technology, applied in the field of pharmaceutical composition and its preparation, to achieve the effect of reduced dosage, good analgesic effect and long-lasting effect

Active Publication Date: 2010-12-22
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine that uses a pharmaceutical composition composed of aconitum alkaloids and the action site of unique flavonoids for anti-inflammatory and analgesic

Method used

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  • Medicinal composition with anti-inflammatory and analgesic effect and preparation method and application thereof
  • Medicinal composition with anti-inflammatory and analgesic effect and preparation method and application thereof
  • Medicinal composition with anti-inflammatory and analgesic effect and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Embodiment 1: pharmaceutical composition tablet of the present invention

[0162] High aconitine total alkaloids 15g, unique flavonoids 95g;

[0163] A. The preparation method of homoaconitum total alkaloids:

[0164] Take the dried Aconitum aconitum, crush it, extract twice with 10 times the weight of 75% ethanol for 2 hours each time, collect and combine the extracts, and recover the ethanol, dissolve the ethanol extract with hydrochloric acid, adjust the pH to 2, After adding sodium hydroxide solution to adjust the pH to 10, extract with chloroform, combine the chloroform solution, recover the chloroform, and dry to obtain the total alkaloids of aconitum;

[0165] B. The preparation method of unique flavonoids:

[0166] The unique medicinal material is extracted twice with an ethanol solution prepared by 70% calcium hydroxide solution 10 times by weight, each extraction is 2 hours, the extracts are collected and combined, filtered, and the filtrate is concentrated at...

Embodiment 2

[0168] Embodiment 2: pharmaceutical composition capsule of the present invention

[0169] High aconitum total alkaloids 95g, unique flavonoids 15g;

[0170] A. The preparation method of homoaconitum total alkaloids:

[0171] Take the dried Aconitum medicinal material, crush it, extract once with 20 times the weight of 65% ethanol, extract for 4.5 hours each time, collect and combine the extracts, and recover the ethanol, dissolve the ethanol extract with hydrochloric acid, adjust the pH to 1, After adding sodium bicarbonate solution to adjust the pH to 11, extract with chloroform, combine the chloroform solution, recover the chloroform, and dry to obtain the total alkaloids of aconitum;

[0172] B. The preparation method of unique flavonoids:

[0173] Extract the unique medicinal material with an ethanol solution prepared by 20 times the weight of 50% sodium carbonate solution for 3 times, each extraction for 1 hour, collect and combine the extracts, filter, and concentrate ...

Embodiment 3

[0175] Embodiment 3: pharmaceutical composition powder of the present invention

[0176] High aconitum total alkaloids 50g, unique flavonoids 50g;

[0177] A. The preparation method of homoaconitum total alkaloids:

[0178] Take the dried Aconitum medicinal material, crush it, extract it with 5 times the weight of 95% ethanol for 3 times, extract for 1 hour each time, collect and combine the extracts, and recover the ethanol, dissolve the ethanol extract with hydrochloric acid, adjust the pH to 3, After adding ammonia water to adjust the pH to 8, extract with chloroform, combine the chloroform solution, recover the chloroform, and dry to obtain the total alkaloids of aconitum;

[0179] B. The preparation method of unique flavonoids:

[0180] The unique medicinal material is extracted 4 times with an ethanol solution prepared by 90% calcium hydroxide solution 5 times by weight, each time for 1 hour, the extracts are collected and combined, filtered, and the filtrate is concen...

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Abstract

The invention provides a medicinal composition with anti-inflammatory and analgesic effect, which is prepared from raw material medicaments of aconitum excelsum reichb and lamiophlomis rotata flavonoids. Through pharmacological research on interaction of the aconitum excelsum reichb and the lamiophlomis rotata flavonoids and the compatability of the medicaments, results show that the medicinal composition can obviously improve the pain threshold value of mice compared with the single aconitum excelsum reichb and single lamiophlomis rotata flavonoids; the medicinal composition is subjected to experiments of acetic acid twisting-body reaction of mice, water bah tail flick reaction of rats, croton oil induced ear edema of mice and carrageenin induced paw edema of rats, so the optimal formula of the medicinal composition is obtained. The medicinal composition has obvious anti-inflammatory and analgesic effect and wide application prospect.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and application, in particular to a drug with anti-inflammatory and analgesic effects, which takes the effective part of Gaoaconitum total alkaloids of Gaoaconitum and the effective part of Duyiwei flavonoids as raw materials The pharmaceutical composition and its preparation method and application. Background technique [0002] Aconitum aconitum is the dry root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. It is excavated in autumn, and the fibrous roots and aerial parts are removed, and the soil is washed away and dried in the sun. Distributed in Xiaowutai Mountain, Yuxian County, Hebei Province, Shanxi, counties east of Riyue Mountain in Qinghai, Shaanxi, Gansu, Hubei, Sichuan and Guizhou provinces. Its root is poisonous, used as medicine, can reduce swelling and pain, promote blood circulation and dissipate blood stasis, expel wind, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P29/00
Inventor 李晓强张朋张国霞张樱山
Owner TIBET QIZHENG TIBETAN MEDICINE
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