7,2'-dehydration puerarin, salt derivatives as well as preparation method and application thereof

Abstract

The invention relates to a compound 7,2''-dehydration puerarin in a structural formula (I) and salt derivatives thereof. The 7,2''-dehydration puerarin is prepared from puerarin through intramolecular Mitsunobu reaction. The invention can remarkably reduce the arrhythmia duration and prolong the cogulation time. The monomer compound and medical salts thereof can be prepared into orally-taken or injection agents and can be used for treating cardiovascular and cerebrovascular diseases of arrhythmia, coronary disease, angina, myocardial infarction, cerebral infarction, and the like.

Description

technical field The invention relates to puerarin derivatives and their preparation methods and applications, in particular to 7,2"-anhydropuerarin and its salt derivatives and their preparation methods and applications, belonging to the technical field of medicine. Background technique Puerarin is a kind of isoflavone glycoside extracted from the roots of Pueraria mirifica and Pueraria vine, which is a leguminous plant. Studies have found that it can scavenge free radicals (J.Agric.Food Chem.2002, 50, 7504-7509.), lower serum cholesterol (J.Nat.Prod.2003, 66, 788-792.), anticoagulant and antiallergic (Biol.Pharm.Bull.2002, 25, 1328-1332.) and other activities, clinically used for the treatment of coronary heart disease (Chinese Journal of Integrated Traditional Chinese and Western Medicine 2003, 23, 895-897.), angina pectoris (Chinese Journal of Integrated Traditional Chinese and Western Medicine 1998, 18, 282-284.), myocardial infarction (Chinese Med.J.1992, 105, 11-17.) ...

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However, after retrieval, no reports of 7,2"-anhydropuerarin derivatives have been found

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