Influenza A virus medicament screening yeast two-hybrid system and application thereof

A two-hybrid technology of influenza A virus and yeast, which is applied in the field of genetic engineering, can solve the problems of screening specificity, low screening throughput, unclear mechanism of action of target drugs, etc., and achieve high specificity effect
CN101921713BInactive Publication Date: 2013-07-31SHENZHEN CENT FOR DISEASE CONTROL & PREVENTION
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN CENT FOR DISEASE CONTROL & PREVENTION
Publication Date
2013-07-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention is suitable for the technical field of genetic engineering, and provides a target specific influenza A virus medicament screening yeast two-hybrid system and application thereof. The target specific influenza A virus medicament screening yeast two-hybrid system comprises an influenza A virus PB1gene and an influenza A virus gene, a PB1 gene and a PA gene, and PB1, PB2 and PA genes. The target specific influenza A virus medicament screening yeast two-hybrid system for medicament screening has the advantages of high specificity, high throughput screening and exact mechanism of a target medicament.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, in particular to a target-specific influenza A virus drug screening yeast two-hybrid system and its application. Background technique

[0002] Influenza viruses belong to the Orthomyxoviridae family (Orthomyxoviridae), which are negative-strand RNA viruses with envelopes. Members include influenza A, B, and C. Currently, influenza A and B mainly infect humans. The genomes of influenza A and B viruses contain 8 segments, which are single-strand and negative-strand RNAs, encoding at least 10 proteins respectively. Influenza A viruses can be divided into 1-16 HA subtypes and 1-9 NA subtypes according to the different antigenic properties of hemagglutinin (HA) and neuraminidase (NA) on the surface of the virus. Influenza viruses currently causing human infections are mainly H1 (N1), H3 (N2) subtypes and B influenza viruses. Influenza virus RNA-dependent RNA polymerase by PB 1 , PB 2 ,...

Claims

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