Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug slow control releaser and preparation method thereof

A technology for controlled release and controlled release of drugs, used in pharmaceutical formulations, drug combinations, drug delivery, etc.

Inactive Publication Date: 2010-12-29
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for small and micro-sized medicine capsules, it is not only difficult to quickly and quantitatively load the medicine powder directly into the medicine capsule by hand, but also the existing mechanical filling method cannot solve the problem of quantitatively filling and sealing medicine powder in small capsules.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug slow control releaser and preparation method thereof
  • Drug slow control releaser and preparation method thereof
  • Drug slow control releaser and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: use polycaprolactone capsule tube to prepare the drug delivery body containing levonorgestrel (LNG)

[0028] A preferred embodiment of the drug-containing core in the present invention is that the drug-containing core is composed of levonorgestrel uniformly distributed in polycaprolactone, wherein: the levonorgestrel accounts for about Containing 65% of the weight of the drug core, namely take 400g of levonorgestrel and 200g of polycaprolactone.

[0029] Of course, the content of the components in the drug-containing core can also be: the levonorgestrel accounts for about 70%, or 75%, or 80% of the total weight of the drug-containing core, and the balance is used as the drug-containing core Any one of polylactic acid, polylactide, polylactic-glycolic acid, polylactide-glycolide, polycaprolactone, polyhydroxybutyric acid, polyurethane and silicone rubber in the second polymeric material of the carrier. Thus, drug-containing cores containing levonorgestrel ...

Embodiment 2

[0036] Embodiment 2: the in vitro drug release test that the drug release body that contains levonorgestrel (LNG) is carried out

[0037] The drug release body containing levonorgestrel (LNG) made in Example 1 is put into 100ml distilled water, and in the constant temperature shaker of 37 ± 2 ℃, the agitation speed of 130 rev / min is kept, every certain time Replace release fluid. Use HPLC to measure the concentration of levonorgestrel in the release liquid, the chromatographic measurement conditions are as described in the literature, and the daily average drug release rate can be calculated according to the measurement results. The drug-containing core prepared in Example 1 was used as a control, and the daily average drug release rate was measured and calculated in the same way.

[0038] Such as figure 2 As shown, the release rate of the drug-containing core forms a peak in the first 6 days in vitro, and then the release rate gradually increases. In the first 3 days outs...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
thicknessaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a drug slow control releaser which comprises a drug controlled-release membrane, wherein a base material of the drug controlled-release membrane is a pharmaceutically acceptable first type polymer material, the drug controlled-release membrane comprises porogen molecules dispersed in the first type polymer material, the drug controlled-release membrane is a drug controlled-release capsule which can form a pore structure on the wall in vivo, and a drug-containing core containing a pharmaceutical effective dose of drug which can be uniformly distributed in a pharmaceutically acceptable second type polymer material and carry out drug administration in vivo is closed in the drug controlled-release capsule. The drug controlled-release membrane has good permeability, and the solid drug-containing core can be quickly and quantitatively placed into the hollow capsule prepared by the release membrane. Tissue fluid can enter into the drug slow control releaser after the drug slow control releaser is implanted into an organism, thereby leading the drug in the drug core to dissolve out rapidly, controlling the release speed of the drug by the drug controlled-release membrane, leading the drug to be released slowly for a long time and absorbed by the organism, and achieving the purpose of long-term drug delivery.

Description

technical field [0001] The invention relates to a drug slow controlled release body and its preparation method, more specifically, the invention relates to packing the drug into a capsule tube with a polymeric material as the base material to obtain the drug slow controlled release body. Background technique [0002] The treatment of some diseases requires long-term administration of small doses, so a therapeutic preparation that is administered once and maintains its effect for a long time is required. In addition, in order to achieve the purpose of long-term anti-fertility, long-acting contraceptive pharmaceutical preparations are also required. At present, for small and micro-sized medicine capsules, it is not only difficult to quickly and quantitatively load medicine powder directly into medicine capsules by hand, but also the existing mechanical filling method cannot solve the problem of quantitatively filling and sealing medicine powder in small capsules. Contents of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/30A61K47/34A61K45/00A61K31/567A61P15/18A61P37/02A61P25/00A61P5/00
Inventor 孙洪范张超
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com