Preparation of macroporous strong-acid cation-exchange resin catalyst and use thereof in catalytic synthesis of methyl 2-keto-L-gulonate

A cation exchange and catalyst technology, which is applied in the direction of catalyst activation/preparation, organic compound preparation, carboxylate preparation, etc., can solve the problems of poor mechanical strength, fragility, and reduced catalyst activity, so as to speed up mass transfer and resist Strong pollution ability and good stability

Inactive Publication Date: 2010-12-29
上海华震科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Preliminary studies have found that the current commercial macroporous strong acid resin and highly cross-linked strong acid resin have high initial catalytic activity and good selectivity, but the pores of the catalytic resin are small and easy to block, which

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Add 800 grams of water and 8 grams of gelatin in a 3000 milliliter four-necked flask equipped with a stirrer, a thermometer and a reflux condenser, and stir to dissolve. Then add the pre-configured monomer phase into the flask, the monomer phase includes 300 grams of styrene, 66 grams of divinylbenzene (55% content), 80 grams of liquid paraffin, 103 grams of di-n-butyl phthalate Esters, 3.66 g benzoyl peroxide initiator. Stir and adjust the rotation speed to gel, heat up to 75°C, keep warm for 4 hours, then raise the temperature to 85°C and keep warm for 6 hours, cool down and discharge, wash with water, wash away the porogen with acetone, dry, and sieve for later use.

[0026] Get 200 grams of gained white balls and sulfonate them according to the preparation method of conventional sulfonic acid cationic resins to obtain a macroporous strong acid cationic exchange resin catalyst with a crosslinking degree of 10%.

Embodiment 2

[0028] As in Example 1, the mixed porogen was changed to 244 grams of liquid paraffin, 122 grams of di-n-butyl phthalate, and other conditions were constant, so that a macroporous strong acid cation exchange resin catalyst with a degree of crosslinking of 10% was obtained.

Embodiment 3

[0030] As in Example 1, the mixed porogen is changed to 366 grams of liquid paraffin, 366 grams of di-n-butyl phthalate, and other conditions are constant, and the obtained crosslinking degree is a macroporous strong acid cation exchange resin catalyst of 10%.

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PUM

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Abstract

The invention belongs to the technical field of biochemical industry and relates to a preparation method of a macroporous strong-acid cation-exchange resin catalyst and the use thereof in the catalytic synthesis of methyl 2-keto-L-gulonate. The preparation method is characterized by comprising the following steps in turn: 1), suspending and polymerizing phenylethylene and polystyrene monomers at 60 to 95 DEG C in the presence of a dispersion system, an initiator and a mixed pore-forming agent to obtain copolymer white balls with a macroporous structure; 2) washing the copolymer white balls with low-boiling point solvent; and 3) sulfonating according to a preparation method of a sulfonie acid cation resin to obtain the macroporous strong-acid cation-exchange resin catalyst. The preparation method has the advantage that an alkyl phthalate is mixed with liquid paraffin or paraffin to form the mixed pore-forming agent and then the strong-acid resin having a macroporous structure is formed. The use of the product in the catalytic synthesis of methyl 2-keto-L-gulonate shows that the quality of the product is much higher than that of commercial macroporous and gel strong acid resins currently available on markets, and that the continuous operation stability and the pollution resistance of the product are high.

Description

technical field [0001] The invention belongs to the technical field of biochemical industry, and relates to a method for preparing a macroporous cation exchange resin catalyst suitable for catalytically synthesizing methyl guronate and its application in catalytically synthesizing methyl guronate. Background technique [0002] Guronic acid methyl esterification is an important intermediate process for the production of vitamin C. At present, the industrial production of guronic acid methyl ester mainly uses guronic acid and methanol as raw materials, and concentrated sulfuric acid is used as a catalyst to catalyze the esterification. There are many side reactions in this reaction, the color of the methyl ester is dark, the quality is poor, and alkali needs to be used for neutralization in the follow-up reaction, which brings difficulties to the follow-up treatment; in addition, the concentrated sulfuric acid has very strong corrosiveness to the equipment. The conditions are ...

Claims

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Application Information

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IPC IPC(8): B01J31/10B01J37/00C07C69/675C07C67/08
Inventor 江邦和宁方红徐环昕王宏民宋海英王淑华
Owner 上海华震科技有限公司
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