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Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof

A technology of colon positioning and film coating, which is applied in the direction of pharmaceutical formulations, drug delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of slow sales and achieve the effects of reducing coating costs, low unit prices, and improving quality stability

Active Publication Date: 2011-01-05
浙江瓯伦包衣技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the long-term existence of the above situation, the current users (or distributors) are quite used to it, so that if the two indicators of polyacrylic resin III deviate from the above range, there may even be unsalable situations that are not wanted.

Method used

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  • Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof
  • Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof
  • Oral colon-specific release film coating premixed accessory of pH dependent type and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Proportion:

[0032] Polyacrylic resin III 40wt%, triethyl citrate 15wt%, talcum powder 40wt%, titanium dioxide 5wt%. Among them, the viscosity value of polyacrylic resin III is 20mPa·s, and the acid value is 220.

[0033] 2. Preparation method:

[0034] (1) Premix 1: Add 40wt% polyacrylic acid resin III and 15wt% triethyl citrate to a tank mixer and mix for 10 minutes;

[0035] (2) Premix 2: Add 40wt% talcum powder, 5wt% titanium dioxide and the mixed material in step (1) to a multi-directional motion mixer and mix for 30 minutes;

[0036] (3) fine mixing: the material mixed through step (2) is added to the grinding mixer, and mixed for 3 minutes;

[0037] (4) Final mixing: Add the material mixed in step (3) into a multi-directional motion mixer and mix for 15 minutes to obtain a film coating premixed auxiliary material that is finally mixed uniformly.

Embodiment 2

[0039] 1. Proportion:

[0040] Polyacrylic resin III 70wt%, triethyl citrate 23wt%, red iron oxide 5.2wt%, black iron oxide 1.8wt%. Among them, the viscosity value of polyacrylic resin III is 35mPa·s, and the acid value is 210.

[0041] 2. Preparation method:

[0042] (1) Premix 1: Add 70wt% polyacrylic acid resin III and 23wt% triethyl citrate to a tank mixer and mix for 30 minutes;

[0043] (2) Premix 2: Add 5.2wt% red iron oxide, 1.8wt% black iron oxide and the mixed material in step (1) to a multi-directional motion mixer and mix for 15 minutes;

[0044] (3) fine mixing: the material mixed through step (2) is added to the grinding mixer, and mixed for 7 minutes;

[0045] (4) Final mixing: Add the material mixed in step (3) into a multi-directional motion mixer and mix for 20 minutes to obtain a film coating premixed auxiliary material that is finally mixed uniformly.

Embodiment 3

[0047] 1. Proportion:

[0048] Polyacrylic resin III 55wt%, triethyl citrate 18wt%, talcum powder 23wt%, red iron oxide 4wt%. Among them, the viscosity value of polyacrylic resin III is 28mPa·s, and the acid value is 215.

[0049] 2. Preparation method:

[0050] (1) Premix 1: Add 55wt% polyacrylic acid resin III and 18wt% triethyl citrate to a tank mixer and mix for 15 minutes;

[0051] (2) Premix 2: Add 23wt% talcum powder, 4wt% red iron oxide and the mixed material in step (1) to a multi-directional motion mixer and mix for 20 minutes;

[0052] (3) fine mixing: the material mixed through step (2) is added to the grinding mixer, and mixed for 10 minutes;

[0053] (4) Final mixing: Add the material mixed in step (3) into a multi-directional motion mixer and mix for 30 minutes to obtain a film coating premixed auxiliary material that is finally mixed uniformly.

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Abstract

The invention relates to an oral colon-specific release film coating premixed accessory of a pH dependent type, characterized by mainly comprising the following components in percentage by weight: 40-70 percent of polyacrylic acid resin III, 15-23 percent of plasticizer and the balance of accessory materials, wherein the polyacrylic acid resin III has the viscosity number of 20-35 mPa*s and the acid number of 210-220. The technical scheme of the invention has the effects of low cost, favorable disintegration release performance and less and non-sensitive coating weight increase.

Description

technical field [0001] The invention relates to a film-coated premixed auxiliary material and a preparation method thereof, more specifically, to a pH-dependent oral colon-localized drug release film-coated premixed auxiliary material and a preparation method thereof. Background technique [0002] Oral colon-directed drug delivery system (OCDDS) refers to the use of appropriate methods to avoid drug release in the stomach, duodenum, jejunum and ileum after oral administration, and release the drug after being transported to the ileocecum and play a local role. It is a new type of drug delivery system with systemic or systemic therapeutic effects, and it is an effective means to treat diseases in the colon and other parts by using targeted positioning technology. Ulcerative colitis, Crohn's and other colon diseases, traditional treatment methods are usually oral tablets, capsules or enema treatment. Ordinary oral preparations are absorbed into the blood circulation in the st...

Claims

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Application Information

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IPC IPC(8): A61K47/32A61K9/32A61K47/02A61K47/14
Inventor 邱湘龙黄建国王小伦方卫卫黄河赵艳红李宏伟陈利明
Owner 浙江瓯伦包衣技术有限公司
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