Micro-embedded medicament carrier and preparation method thereof

A nano-carrier and drug technology, which is applied in the field of micro-encapsulated drug carrier and its preparation, can solve the problems of single means of regulating drug dissolution rate, drug cross-contamination, and insufficient protection of drug activity, and achieve cross-interference and commonly used micro/nano Effects of carrier burst release, reduction of toxic and side effects, and inhibition of burst release effect

Active Publication Date: 2011-01-19
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problems of drug burst release effect in the current drug sustained release system, single means for adjusting drug dissolution rate, insufficient protection of drug activity, and possible drug cross-contamination in drug combined sustained release treatment, and has the advantages of simple process and convenient operation features

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A micro-encapsulated drug carrier forms a drug carrier of a micro-encapsulated system by embedding nano-carriers inside the microcapsules, and the drugs are respectively loaded inside the nano-particles or between different nanoparticles in the micro-capsule. The particle size of the nano carrier is between 100-1000 nm, and the particle size of the micro-inclusion system is between 100-1000 μm.

[0021] The preparation method of a microencapsulated drug carrier of this embodiment includes the following preparation steps: (1) A sodium alginate solution with a concentration of 1.0% (w / v) is passed through 0.8μm, 0.45μm, and 0.22μm micropores. Membrane filtration is used as the water phase, and the isooctane solution of Span 80 with a concentration of 4.0% (w / v) is the oil phase. Mix the same volume of the water phase and the oil phase, and use a stirrer 1500rpm to fully stir, mix and emulsify. After W / O system, add 2mL Tween 80 aqueous solution to adjust HLB to 6.0, continue...

Embodiment 2

[0025] This embodiment is basically the same as embodiment 1, except that the sodium alginate solution in the syringe pump is mixed with 1 mg / mL fluorouracil. The microencapsulation system with different internal spaces for distributing different drugs is prepared, that is, BSA is embedded in the nanocapsule, and fluorouracil is embedded in the microcapsule outside the nanocapsule. The microencapsulated nano-system has drug loading levels of 7.07% and 0.23% for BSA and fluorouracil, respectively, and the encapsulation efficiency is 63.78% and 29.32%, respectively. The simulated release of microencapsulated nano-system in vitro showed that the cumulative release of fluorouracil exceeded 80%, while BSA was only about 10%. The novel micro-encapsulated drug carrier of the present embodiment further improves the long-term release and absorption of the drug after being mixed with fluorouracil in the sodium alginate solution, and reduces the toxic and side effects of simply using the ...

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Abstract

The invention discloses a micro-embedded medicament carrier and a preparation method for the carrier. A nano-carrier is embedded in a microcapsule so as to form a medicament carrier of a micro-embedded system, and medicaments are respectively carried in nanoparticles or among different nanoparticles in the microcapsule. The micro-embedded medicament carrier solves the problems of medicament burst effect, single means of adjusting a medicament dissolution rate, insufficient protection of medicament activity and possible medicament cross contamination in medicament combination sustained-release treatment of the conventional medicament sustained-release system, and has the characteristics of simple process, convenient operation, high practicality and wide application prospect.

Description

Technical field [0001] The invention relates to a micro-encapsulated drug carrier and a preparation method thereof. Background technique [0002] With the in-depth research on drug carrier systems, in recent years, microcapsules / balls and other particulate drug slow-release systems have been developed rapidly, and have also been widely used in clinical practice. In addition, due to the wide variety of diseases and complex pathogenic mechanisms, single drug therapy and drug slow-release systems often fail to achieve the desired therapeutic effect. The use of drug combination therapy can solve this problem to some extent. Therefore, combining drug combination therapy and drug carrier system to achieve slow / controlled drug release therapy can reduce the frequency of drug administration and relieve the suffering of patients. However, the current drug slow-release microcapsules / balls often face problems such as the drug burst effect, the single method of adjusting the drug dissolutio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/52A61K47/34A61K47/36A61K47/22
Inventor 刘源岗王士斌毛鸿浩孙学战刘玉先陈爱政
Owner HUAQIAO UNIVERSITY
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