Micro-embedded medicament carrier and preparation method thereof

A nano-carrier and drug technology, which is applied in the field of micro-encapsulated drug carrier and its preparation, can solve the problems of insufficient protection of drug activity, single means of adjusting drug dissolution rate, drug cross-contamination, etc., to solve cross-interference and commonly used micro/nano The effect of carrier burst release, inhibition of burst release effect, and reduction of toxic and side effects

Active Publication Date: 2012-10-10
HUAQIAO UNIVERSITY
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problems of drug burst release effect in the current drug sustained release system, single means for adjusting drug dissolution rate, insufficient protection of drug activity, and possible drug cross-contamination in drug combined sustained release treatment, and has the advantages of simple process and convenient operation features

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A microencapsulated drug carrier, which forms a microencapsulated drug carrier by embedding nanocarriers inside the microcapsules, and the drugs are respectively carried inside the nanoparticles or between different nanoparticles in the microcapsules. The particle size of the nano-carrier is between 100-1000nm, and the particle size of the micro-encapsulation system is between 100-1000μm.

[0021] A preparation method of a microencapsulated drug carrier according to the present embodiment comprises the following preparation steps: (1) using an aqueous sodium alginate solution with a concentration of 1.0% (w / v), passing through micropores of 0.8 μm, 0.45 μm, and 0.22 μm Membrane filtration is used as the water phase, and the isooctane solution of Span 80 with a concentration of 4.0% (w / v) is the oil phase. Mix the same volume of the water phase and the oil phase, and use a stirrer at 1500 rpm to fully stir and mix to form an emulsified After the W / O system, add 2 mL of T...

Embodiment 2

[0025] This embodiment is basically the same as Embodiment 1, except that the sodium alginate solution in the syringe pump is mixed with 1 mg / mL fluorouracil. A microencapsulation system for distributing different drugs in different internal spaces was prepared, that is, BSA was embedded inside the nanocapsule, and fluorouracil was embedded in the microcapsule outside the nanocapsule. The drug loadings of BSA and fluorouracil in the microencapsulation system were 7.07% and 0.23%, respectively, and the encapsulation efficiencies were 63.78% and 29.32%, respectively. The cumulative release of fluorouracil was more than 80% in the simulated release in vitro of the microencapsulation system until the 7th day, while that of BSA was only about 10%. The new microencapsulated drug carrier of this embodiment further improves the long-term release and absorption of the drug after being mixed with fluorouracil in the sodium alginate solution, and reduces the toxic and side effects of the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a micro-embedded medicament carrier and a preparation method for the carrier. A nano-carrier is embedded in a microcapsule so as to form a medicament carrier of a micro-embedded system, and medicaments are respectively carried in nanoparticles or among different nanoparticles in the microcapsule. The micro-embedded medicament carrier solves the problems of medicament bursteffect, single means of adjusting a medicament dissolution rate, insufficient protection of medicament activity and possible medicament cross contamination in medicament combination sustained-releasetreatment of the conventional medicament sustained-release system, and has the characteristics of simple process, convenient operation, high practicality and wide application prospect.

Description

technical field [0001] The invention relates to a microencapsulated drug carrier and a preparation method thereof. Background technique [0002] With the deepening of people's research on drug carrier systems, in recent years, microcapsules / spheres and other particulate drug sustained-release systems have developed rapidly and have been widely used in clinical practice. In addition, due to the wide variety of diseases and complex pathogenic mechanisms, single drug therapy and drug sustained release system often cannot achieve the desired therapeutic effect, and drug combination therapy can solve this problem to some extent. Therefore, combined with drug combination therapy and drug carrier system to achieve slow / controlled release of drugs, it can reduce the frequency of drug application and alleviate the suffering of patients. However, at present, drug sustained-release microcapsules / spheres often face problems such as drug burst effect, single means of regulating drug dis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/52A61K47/34A61K47/36A61K47/22
Inventor 刘源岗王士斌毛鸿浩孙学战刘玉先陈爱政
Owner HUAQIAO UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap