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Gel patch matrix and preparation method and application thereof

A gel patch and matrix technology, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. Less problems such as preventing skin residues, ensuring shapeability, and increasing drug loading

Inactive Publication Date: 2011-01-19
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patch made of the matrix described in the above patent application has the advantages of high water retention and convenient peeling off, etc., but there are still some problems such as small drug holding capacity, low viscosity, easy to fall off, and insufficient tensile strength, which is easy to remain on the skin after peeling off. Insufficient surface etc.

Method used

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  • Gel patch matrix and preparation method and application thereof
  • Gel patch matrix and preparation method and application thereof

Examples

Experimental program
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Effect test

example 1

[0021] 1. Formula and proportion:

[0022] Sodium polyacrylate 6g, gelatin 5g, carbomer 980 2g, carbomer 981 2g, triethanolamine 5g, polyvinylpyrrolidone K-30 2.5g, glycerin 15g, aluminum glycinate 0.5g, water 150ml.

[0023] 2. Preparation method:

[0024] (1) Disperse sodium polyacrylate with glycerin, add 60ml of water and stir evenly, then add gelatin, heat to 90°C to dissolve, stir evenly to obtain phase I;

[0025] (2) Take Carbomer 980 and Carbomer 981 and add 60ml of water to swell for 12 hours, then add triethanolamine and stir well to obtain phase II;

[0026] (3) Take polyvinylpyrrolidone K-30 and add 30ml of water, heat to 90°C to dissolve, and obtain phase IV;

[0027] (4) Disperse aluminum glycinate in 10 mL of water to obtain phase IV;

[0028] (5) Add phase II and III into phase I, stir evenly, then add phase IV, stir evenly, add citric acid (50%) to adjust the pH to 6, and obtain.

example 2

[0030] 1. Formula and proportion:

[0031] Sodium polyacrylate 2g, gelatin 1g, carbomer 9804g, carbomer 9814g, triethanolamine 10g, polyvinylpyrrolidone K-305g, glycerin 5g, aluminum glycinate 0.1g, water 180mL.

[0032] 2. Preparation method:

[0033] (1) Disperse sodium polyacrylate with glycerin, add 20mL of water, stir until uniform, add gelatin, heat and melt at 90°C, and stir uniformly to obtain phase I;

[0034] (2) Carbomer 980 and 981 were swollen with 120 mL of water for 12 hours, then added triethanolamine and stirred to obtain phase II;

[0035] (3) Add 30 mL of water to polyvinylpyrrolidone K-30, heat and dissolve at 90°C to obtain phase IV;

[0036] (4) Disperse aluminum glycinate in 10 mL of water to obtain phase IV;

[0037] (5) Add phase II and III into phase I, stir evenly, then add phase IV, stir evenly, add citric acid (50%) to adjust the pH to 6.1, and obtain.

example 3

[0039] 1. Formula and proportion:

[0040] Sodium polyacrylate 10g, gelatin 8g, carbomer 980 0.5g, carbomer 981 0.5g, triethanolamine 1g, polyvinylpyrrolidone K-30 2g, glycerin 25g, aluminum glycinate 1g, water 145mL

[0041] 2. Preparation method:

[0042] (1) Disperse sodium polyacrylate with glycerin, add 100mL of water, stir until uniform, add gelatin, heat and melt at 90°C, and stir uniformly to obtain phase I;

[0043] (2) Add 15 mL of water to carbomer 980 and 981 to swell for 12 hours, then add triethanolamine and stir well to obtain phase II;

[0044] (3) Add 20 mL of water to polyvinylpyrrolidone K-30, heat and dissolve at 90°C to obtain phase IV;

[0045] (4) Disperse aluminum glycinate in 10 mL of water to obtain phase IV;

[0046] (5) Add phase II and III into phase I, stir evenly, then add phase IV, stir evenly, add citric acid (50%) to adjust the pH to 6.2, and obtain the product.

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Abstract

The invention relates to a gel patch matrix. The matrix is prepared from the following components in part by weight: 2 to 10 parts of sodium polyacrylate, 1 to 10 parts of gelatin, 0.5 to 4 parts of carbomer 980, 0.5 to 4 parts of carbomer 981, 1 to 10 parts of triethanolamine, 0.5 to 5 parts of polyvinylpyrrolidone K-30, 5 to 25 parts of glycerin, 0.1 to 1 part of aluminum glycinate and a proper amount of water. A water-insoluble cross-linked gel structure is formed by both the matrix which is prepared by introducing organic aluminum ions from the aluminum glycinate and the sodium polyacrylate, so that the cohesive strength of the matrix is obviously enhanced and the forming performance of the matrix is improved. Gel patches for various treatment purposes can be prepared by mixing the matrix and active ingredients in a mixing ratio of 0.5-2:1.

Description

technical field [0001] The invention relates to a composition containing a high molecular polymer and an alcohol substance, which is suitable for the matrix of a gel patch. Background technique [0002] Traditional Chinese medicine external treatment has the theory that "the principle of external treatment is the principle of internal treatment; the medicine of external treatment is the medicine of internal treatment, and the difference is the law." "Transdermal drug delivery" has been found in the Chinese medical classic "Nei Jing Su Wen" as early as the second century BC. Traditional Chinese medicine transdermal dosage forms include black plasters, adhesive plasters, pastes, ironing agents and other dosage forms. These traditional dosage forms have certain shortcomings, or pollute clothes; or the dosage is not easy to control; The irritation or (and) toxicity of the drug may lead to adverse reactions such as skin allergies and local redness and swelling when the patient u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K9/70A61K36/00A61K47/16A61K47/18A61K47/32
Inventor 刘强刘莉
Owner SOUTHERN MEDICAL UNIVERSITY
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