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Gel patch matrix and preparation method and application thereof

A gel patch and matrix technology, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. Less problems such as preventing skin residues, ensuring shapeability, and increasing drug loading

Inactive Publication Date: 2012-07-04
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patch made of the matrix described in the above patent application has the advantages of high water retention and convenient peeling off, etc., but there are still some problems such as small drug holding capacity, low viscosity, easy to fall off, and insufficient tensile strength, which is easy to remain on the skin after peeling off. Insufficient surface etc.

Method used

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  • Gel patch matrix and preparation method and application thereof
  • Gel patch matrix and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] 1. Formula and ratio:

[0022] Sodium polyacrylate 6g, gelatin 5g, carbomer 980 2g, carbomer 981 2g, triethanolamine 5g, polyvinylpyrrolidone K-30 2.5g, glycerol 15g, aluminum glycinate 0.5g, water 150ml.

[0023] 2. Preparation method:

[0024] (1) Disperse sodium polyacrylate with glycerin, add 60ml of water and stir evenly, then add gelatin, heat to 90°C to melt, stir evenly to obtain phase I;

[0025] (2) Take Carbomer 980 and Carbomer 981 and add 60ml of water to swell for 12 hours, then add triethanolamine and stir to obtain phase II;

[0026] (3) Take polyvinylpyrrolidone K-30 and add 30ml of water, and heat to 90℃ to dissolve to obtain phase III;

[0027] (4) Disperse aluminum glycinate in 10 mL of water to obtain phase IV;

[0028] (5) Add phase II and phase III to phase I, stir evenly, then add phase IV, stir evenly, add citric acid (50%) to adjust the pH to 6, and get it.

example 2

[0030] 1. Formula and ratio:

[0031] Sodium polyacrylate 2g, gelatin 1g, carbomer 9804g, carbomer 9814g, triethanolamine 10g, polyvinylpyrrolidone K-305g, glycerol 5g, aluminum glycinate 0.1g, water 180mL.

[0032] 2. Preparation method:

[0033] (1) Disperse sodium polyacrylate with glycerin, add 20 mL of water, stir until uniform, add gelatin, heat at 90°C to melt, and stir to obtain phase I;

[0034] (2) Carbomer 980, 981 was swelled with 120 mL of water for 12 hours, and then triethanolamine was added and stirred to obtain phase II;

[0035] (3) Polyvinylpyrrolidone K-30 is added with 30 mL of water and heated at 90°C to dissolve to obtain phase III;

[0036] (4) Disperse aluminum glycinate in 10 mL of water to obtain phase IV;

[0037] (5) Add phase II and phase III to phase I, stir evenly, then add phase IV, stir evenly, add citric acid (50%) to adjust the pH to 6.1, and it is ready.

example 3

[0039] 1. Formula and ratio:

[0040] Sodium polyacrylate 10g, gelatin 8g, carbomer 980 0.5g, carbomer 981 0.5g, triethanolamine 1g, polyvinylpyrrolidone K-30 2g, glycerol 25g, aluminum glycinate 1g, water 145mL

[0041] 2. Preparation method:

[0042] (1) Disperse sodium polyacrylate with glycerin, add 100 mL of water, stir until uniform, add gelatin, heat at 90°C to melt, and stir to obtain phase I;

[0043] (2) Carbomer 980, 981 was swelled with 15 mL of water for 12 hours, and then triethanolamine was added and stirred to obtain phase II;

[0044] (3) Polyvinylpyrrolidone K-30 is added with 20mL of water and heated at 90°C to dissolve to obtain phase III;

[0045] (4) Disperse aluminum glycinate in 10 mL of water to obtain phase IV;

[0046] (5) Add phase II and phase III to phase I, stir evenly, then add phase IV, stir evenly, add citric acid (50%) to adjust the pH to 6.2, and it is ready.

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Abstract

The invention relates to a gel patch matrix. The matrix is prepared from the following components in part by weight: 2 to 10 parts of sodium polyacrylate, 1 to 10 parts of gelatin, 0.5 to 4 parts of carbomer 980, 0.5 to 4 parts of carbomer 981, 1 to 10 parts of triethanolamine, 0.5 to 5 parts of polyvinylpyrrolidone K-30, 5 to 25 parts of glycerin, 0.1 to 1 part of aluminum glycinate and a properamount of water. A water-insoluble cross-linked gel structure is formed by both the matrix which is prepared by introducing organic aluminum ions from the aluminum glycinate and the sodium polyacrylate, so that the cohesive strength of the matrix is obviously enhanced and the forming performance of the matrix is improved. Gel patches for various treatment purposes can be prepared by mixing the matrix and active ingredients in a mixing ratio of 0.5-2:1.

Description

Technical field [0001] The invention relates to a composition containing a high molecular polymer and an alcohol substance, which is suitable for the matrix of a gel patch. Background technique [0002] Traditional Chinese medicine has the theory of "external treatment, that is, internal treatment; external treatment, that is, internal treatment, which is different." "Transdermal drug delivery" has been seen in the Chinese medical classics "Inner Classics·Suwen" as early as the second century BC. The traditional transdermal dosage forms of traditional Chinese medicine include black plasters, adhesive plasters, pastes, irons and other dosage forms. These traditional dosage forms have certain shortcomings, or contaminate clothes; or the dosage is not easy to control; or the auxiliary materials and matrix of the dosage form itself have certain The irritation or (and) toxicity of the drug may cause adverse reactions such as skin allergies, local redness and swelling when taking the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K9/70A61K36/00A61K47/16A61K47/18A61K47/32
Inventor 刘强刘莉
Owner SOUTHERN MEDICAL UNIVERSITY
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