Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Bioartificial liver support system and combined type liquid storage tank thereof

A liver support system and bioartificial technology, applied in the direction of blood circulation treatment, etc., can solve the problems affecting the material exchange efficiency between hepatic failure plasma and bioreactor, the interference of one-way flow of plasma in double chambers, and the limitation of extraction speed, etc., to achieve improved The effect of material exchange efficiency, avoiding invalid circulation, and stable operation

Active Publication Date: 2013-03-13
ZHEJIANG UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The relatively mature bioartificial liver support systems that have been developed abroad include AMC-BAL, BLSS, ELAD, HepatAssist, MELS, etc. There are roughly two types of problems: 1) The speed of liver failure plasma flowing through the bioreactor is not installed. It can only be consistent with the extraction speed of hepatic failure plasma from the patient's body, and the extraction speed of plasma from the liver failure patient is strictly limited according to the patient's physiological condition, which affects the material exchange between the liver failure plasma and the bioreactor efficiency
2) Using a single-chamber reservoir, although the speed of hepatic failure plasma flowing through the bioreactor can greatly exceed the extraction speed of hepatic failure plasma from the patient's body, the purified plasma that has flowed through the bioreactor is different from the one that has not flowed through the bioreactor. The hepatic failure plasma is directly mixed, and it is unavoidable that part of the hepatic failure plasma returns to the patient without interacting with the liver cells in the bioreactor. The existence of ineffective circulation is its serious defect
However, in the process of bioartificial liver treatment using the double-chamber reservoir, the one-way flow between the purified plasma that has been treated by the bioreactor and the hepatic failure plasma that has not been treated by the bioreactor is realized by the suction of the pump. Yes, the one-way flow of plasma in the double chamber will be disturbed in the event of mechanical failures such as unexpected pump stop and operating errors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bioartificial liver support system and combined type liquid storage tank thereof
  • Bioartificial liver support system and combined type liquid storage tank thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention will be described in detail below according to the accompanying drawings, which will make the purpose and effect of the present invention easier to understand.

[0016] Such as figure 1 As shown, the combined liquid storage pool used in the bioartificial liver support system of the present invention is mainly composed of a closed liquid inlet pool 1 and a closed liquid return pool 2 . The liquid inlet pool 1 and the liquid return pool 2 can be cylindrical containers with exactly the same size, made of transparent plexiglass; the pool height is 7cm, the bottom surface diameter is 6cm, and the volume is about 200ml, except for the wall thickness. The top of the liquid inlet pool 1 is provided with a first liquid inlet 4 and a first air pressure balance hole 7 , and the bottom is provided with a first liquid outlet 5 and a second liquid inlet 6 . The top of the return pool 2 has a third liquid inlet 8 and a second air pressure balance hole 11 , and t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a bioartificial liver support system and a combined type liquid storage tank thereof, wherein the combined type liquid storage tank comprises a closed liquid inlet tank and a closed liquid return tank; the top of the liquid inlet tank is provided with a first liquid inlet and a first air pressure balancing hole; the bottom of the liquid inlet tank is provided with a first liquid outlet and a second liquid inlet; the top of the liquid return tank is provided with a third liquid inlet and a second air pressure balancing hole; the bottom of the liquid return tank is provided with a second liquid outlet and a third liquid outlet; and the second liquid outlet is communicated with the second liquid inlet by a first communicating pipe which is provided with a direction and flow control device. The invention can improve material interchange efficiency between hepatic failure blood plasma and a bioreactor, avoids futile cycle, does not need to depend on the chimney effect of pumps, has simple structure and stable operation and has improvement of the bioartificial liver support system. In the invention, volume of the liquid inlet tank and the liquid return tank can be adjusted according to specific requirements to suit clinical application.

Description

technical field [0001] The invention relates to a medical device for treating a bioartificial liver, in particular to a device capable of effectively improving the treatment effect of a bioartificial liver and a combined liquid storage tank thereof, belonging to the technical field of biomedicine. Background technique [0002] The bioartificial liver support system is a device that provides extracorporeal liver function support for patients with liver failure. The emergence of this technology has opened up a new way for the treatment of liver failure. The basic principle is to place primary hepatocytes isolated in vitro (pig hepatocytes, human hepatocytes, etc.) or hepatocyte strains cultured in vitro (immortalized hepatocyte strains, etc.) Through material exchange between the semipermeable membrane with a certain molecular cutoff and liver cells, the therapeutic purpose of correcting metabolic disorders can be achieved. In this field, research on cell sources and bioreact...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36
Inventor 李兰娟赵立夫张安业吕国良潘小平章益民周鹏程李建州虞晓鹏杨英陈月美陈佳佳
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products