Detection system and method of characteristic substance

Abstract

The invention relates to a detection system and method of a characteristic substance. The method comprises: step 1, analyzing tested samples by mass spectrometry to obtain mass spectrometric data of each sample point and determining areas of interest of tested samples; step 2, for the substances characterized by the same m / z, respectively calculating the total ion strength of all sample points inside and outside the areas of interest, the mean strength of all sample points inside and outside the areas of interest and / or the spatial aggregation of the substance characterized by m / z inside the areas of interest, and judging whether the substance characterized by m / z is the characteristic substance according to pre-set rules. Researchers can accurately and precisely analyze and detect which substances are specific substances of the samples and which substances are background noises inside the areas of interest, relative contents of all characteristic substances and spatial distribution within the samples.

Description

technical field [0001] The invention relates to the field of qualitative and quantitative analysis of characteristic substances, in particular to a detection system and method for characteristic substances. Background technique [0002] The method of mass spectrometry is to ionize material particles (atoms, molecules) into ions, and separate them according to the space position and time sequence through an appropriate stable or changing electric field or magnetic field to achieve mass-to-charge ratio separation, and detect their intensity for qualitative, Analytical methods for quantitative analysis. Due to the nature of direct measurement and the characteristics of high sensitivity, high resolution, high throughput and high applicability, mass spectrometer and mass spectrometry technology play an important role in modern science and technology. With the development of life sciences, environmental sciences, medical sciences, nanomaterials and other disciplines, as well as t...

AI Technical Summary

Problems solved by technology

It solves the problem of confirming whether the sample is contaminated before analysis, the area where the sample needs to be analyzed, and not blindly analyzing; after the sample analysis, the corresponding connection between the actual optical image of the sample and the mass spectrometry data obtained by the analysis solves the problem that the mass spectrometry data cannot be traced to the actual sample Point problem; by applying high-resolution optical images to draw the region of interest, to solve the problem of accurate and precise drawing of the region of interest; in this region, which is the characteristic substance, how much is the relative concentration, and what area is distributed in the sample It also solves which substances are unique to the region, the content and spatial distribution of the unique substances

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