Solid dispersion containing celecoxib as well as preparation method and application thereof

A technology of solid dispersion and celecoxib, which is applied in the field of solid dispersion containing celecoxib and its preparation, and can solve the problems of difficulty in swallowing, limited total amount of solution, instability and the like
CN102000018AInactive Publication Date: 2011-04-06NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
Publication Date
2011-04-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a solid dispersion containing celecoxib as well as a preparation method and application thereof. The invention needs to solve the technical problems of difficult pulverization of raw materials and difficult preparation of solid oral preparation of celecoxib. The solid dispersion is a solid dispersion containing the celecoxib and polyethylene glycol which are in the weight ratio of 1:0.5-10. The preparation method comprises the following steps of: melting solid polyethylene glycol by heating, adding the celecoxib and dissolving to obtain a clear solution; or mixing and heating the solid polyethylene glycol and the celecoxib, and melting to obtain a clear solution; and then rapidly cooling to obtain the solid dispersion. The solid dispersion can be prepared into various oral preparations after being pulverized.
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Description

technical field

[0001] The invention relates to a medicine for treating rheumatoid arthritis, in particular to a solid dispersion containing celecoxib and its preparation method and application. Background technique

[0002] Celecoxib (Celecoxib) is a medicine for the treatment of rheumatoid arthritis, rheumatoid arthritis and osteoarthritis listed by Pfizer in 1999. has the following structure:

[0003]

[0004] Celecoxib has poor physicochemical properties due to its crystal structure. The main performances are: insoluble in water, low bulk density, easy to bond, and poor compressibility. Celecoxib is insoluble in water, is encapsulated as an uncrushed powder, and is slowly absorbed when taken orally. World patent WO0032189 (Chinese patent CN99802185.7) reports that celecoxib raw material is crushed to D 90 Below 200 μm, preferably 1-10 μm, most preferably 5-7 μm, the preparation is made according to conventional methods, which can effectively treat blood concentrat...

Claims

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