Method for preparing cholate from stock of chenodeoxycholic acid-extracted chicken gall
A technology of chenodeoxycholic acid and bile salts, which is applied in the field of bile salt preparation, can solve problems such as large market demand, soaring prices, and tight markets, and achieve good bacterial culture effects and strong social value
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example 1
[0030] Dissolve and transform, take 60kg of blanks and smash them into a salt-forming kettle, add 480kg of 91.5° (alcohol degree) methanol, heat and stir to reflux for 2 hours, adjust the end point pH value to 9.15 with saturated NaOH aqueous solution, and then add 6kg of saturated CaCl 2 Aqueous solution, the alcohol meter reading is 59 °, continue to reflux for 1 hour, leave it to cool for 24 hours, and obtain a bile acid calcium solution for use;
[0031] Filtrate and concentrate the crystallization, filter the bile acid calcium solution obtained above to obtain primary slag and bile acid calcium clear liquid, incinerate the slag, send the bile acid calcium clear liquid to concentrated crystallization, concentrate at normal pressure until the recovery of methanol is at 50°, and centrifuge immediately Filter to obtain 90kg of anhydrous bile acid calcium crystals (calcium salt), and methanol returns to the salt-forming kettle for reuse;
[0032] Alkali-soluble filtration, ad...
example 2
[0035] Feed 50kg, add 400kg93°methanol in the salt-forming kettle, the end point pH value is 10.9, then add 6kg saturated CaCl 2 Aqueous solution, the alcohol meter reading is 59°, concentrated at normal pressure until methanol is recovered at 52°, and 72kg of calcium salt is obtained after secondary centrifugal filtration, 600kg of water is added to the alkali-dissolving kettle, the calcium salt is stirred, and 11kg of Na 2 CO 3 The produced sodium bile acid solution was sent to a refining tank to be concentrated into a paste, then added 380kg of 98° methanol and 3.8kg of activated carbon for decolorization, stirred and refluxed for 30 minutes, cooled, and the slag was incinerated and discarded. The above specific operations and the rest were the same as in Example 1. 34.8kg of bile salts were obtained, with a yield of 69.6%.
example 3
[0037] Feed 50kg, add 400kg90.5°methanol in the salt forming kettle, the end point pH value is 11.8, then add 6kg saturated CaCl 2 Aqueous solution, the alcohol meter reading is 57.2 °, concentrated at normal pressure until the recovery of methanol 53 °, immediately centrifuged to obtain 75kg of calcium salt, add 600kg of water to the alkali-dissolving kettle, stir into the calcium salt, add 11kg of Na 2 CO 3 After the sodium bile acid solution of output is sent to the refining kettle to concentrate to paste, add 380kg96.5 ° of methyl alcohol and 3.8kg gac for decolorization, the above specific operations and all the other are with example 1. 36.5 kg of bile salts were obtained, with a yield of 73%.
[0038]
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