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Kit for detecting tuberculosis treatment effect

A treatment effect, tuberculosis technology, applied in the direction of measuring devices, microbe determination/inspection, instruments, etc., can solve the problem of lack of specificity in X-ray chest film examination

Inactive Publication Date: 2011-05-18
程小星 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chest X-rays lack specificity

Method used

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Examples

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Effect test

Embodiment 1

[0011] Example 1. Tuberculosis-specific immune molecular markers are used to monitor the efficacy of tuberculosis treatment

[0012] The inventors have discovered a new immune molecular marker that can be used to monitor the efficacy of tuberculosis treatment, and to guide the clinical treatment of tuberculosis (especially drug-resistant tuberculosis). CD27 plays a very important role in cellular immunity. In the previous study, through the comparative study of tuberculosis patients and normal controls, it was found that the reduction of CD27 expression in tuberculosis antigen-specific CD4 T cells was related to the failure of tuberculosis treatment, and it is expected to be used as an immune molecular marker for monitoring the effect of tuberculosis treatment.

[0013] According to the above findings, we designed a method for monitoring the effect of tuberculosis treatment, which includes the steps of obtaining peripheral blood mononuclear leukocytes, labeling tuberculosis an...

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PUM

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Abstract

The invention discloses a kit for detecting a tuberculosis treatment effect. The kit comprises the following reagents: (1) a fluorescence labeled anti-human CD4 (Cluster of Differentiation) antibody; (2) a fluorescence labeled anti-human CD154 antibody; and (3) a fluorescence labeled anti-human CD27 antibody. Compared with the traditional acid-fast stain or tubercle bacillus cultivation, the detection by utilizing the kit for identifying the tuberculosis treatment effect has the advantages of rapidness, simplicity and high sensitivity, and a tuberculosis treatment result can be obtained within two days just by taking 2ml of blood from a patient. The detection has a guidance effect on the clinical treatment of the tuberculosis (especially the drug-resistant tuberculosis).

Description

technical field [0001] The invention relates to a kit for detecting the treatment effect of tuberculosis. Background technique [0002] Tuberculosis treatment requires a combination of multiple antibiotics for at least 6 months. Due to severe side effects and poor patient compliance, drug-resistant tuberculosis can lead to treatment failure. Currently, monitoring of tuberculosis treatment effect mainly relies on acid-fast staining or negative tuberculosis culture conversion (Holtz TH, Sternberg M, Kammerer S, Laserson KF, Riekstina V, Zarovska E, Skripconoka V, Wells CD, Leimane V. Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome. Ann Intern Med 2006; 144: 650-659), or improvement of lesions on chest X-ray examination. Although acid-fast staining is simple and easy to perform and has high specificity, its sensitivity is low, and the culture of Mycobacterium tuberculosis takes 4 to 8 weeks. Chest X-rays ...

Claims

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Application Information

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IPC IPC(8): G01N33/569G01N33/533C12Q1/04
Inventor 程小星蒋静王心静曹志红
Owner 程小星
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