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Enteric targeted tilmicosin particles and preparation method thereof

A technology of tilmicosin and granules, which is applied in the field of enteric-coated targeted granules and its preparation, can solve the problems of drug administration failure, anorexia of livestock and poultry, etc., and achieve the effect of solving the difficulty of drug administration

Inactive Publication Date: 2011-05-25
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention develops an enteric-coated targeting granule and its preparation method, in order to solve the problem of drug administration failure caused by symptoms such as anorexia and nausea in livestock and poultry during the administration process, and provides a tilmicosin enteric-coated targeting granule. Granules and methods for their preparation

Method used

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  • Enteric targeted tilmicosin particles and preparation method thereof
  • Enteric targeted tilmicosin particles and preparation method thereof
  • Enteric targeted tilmicosin particles and preparation method thereof

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specific Embodiment approach 1

[0007] Specific embodiment 1: The tilmicosin enteric-coated targeted granules of this embodiment are composed of tilmicosin granules and a coating liquid, and the tilmicosin granules are composed of tilmicosin and a binder, and the mass ratio of the two is For tilmicosin: binder=5~2:1, the mass concentration of resin in the coating liquid is 10%-20%, the mass concentration of plasticizer is 10%-25%, the mass concentration of Tween 80 0.5%-15%, and the mass concentration of cyclamate is 0.5%-15%.

specific Embodiment approach 2

[0008] Specific embodiment two: the difference between this embodiment and specific embodiment one is: tilmicosin granules are composed of tilmicosin by mass ratio: binder=3:1, and the mass concentration of resin in the coating solution is 10 %, the mass concentration of the plasticizer is 15%, the mass concentration of Tween 80 is 3%, and the mass concentration of cyclamate is 3%.

specific Embodiment approach 3

[0009] Specific embodiment three: the preparation method of the tilmicosin enteric-coated targeting granules of the present embodiment is carried out according to the following steps: 1. Adhesive preparation: starch is added to water, and the mass ratio of the two is starch: water=1:1 ~1.5, stir and mix, add boiling water and stir again, configure the starch slurry of mass concentration 5%~10%, promptly make adhesive; Two, granulate: by mass ratio tilmicosin: adhesive= Mix the two at a ratio of 5 to 2:1, stir and mix to obtain a soft material, pass the soft material through a 40-mesh sieve to make wet granules, and place the wet granules in an oven at 50°C to 80°C to dry for 10 minutes to 60 minutes, and then 20 mesh sieves are sized to obtain tilmicosin granules; 3. Preparation of coating solution: prepare a plasticizer according to the mass ratio of dibutyl phthalate: castor oil=0.1-100: 1; mix resin and plasticizer Add water respectively to configure a resin-plasticizer mix...

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Abstract

The invention discloses enteric targeted tilmicosin particles and a preparation method thereof, which relate to the enteric targeted particles and the preparation method thereof and aim to solve the problems of difficulties in administration in an administration process. The enteric targeted tilmicosin particles consist of tilmicosin, a bonding agent and a coating fluid. The preparation method for the enteric targeted tilmicosin particles is implemented by the following steps of: 1, preparing the bonding agent; 2, preparing particles; 3, preparing the coating fluid; 4, coating the particles; and 5, drying the particles. In the invention, enteric coating technology is adopted, the tilmicosin is prepared into the enteric targeted particles, and the intrinsic bitterness and irritation of the medicaments are hidden, thereby solving the problems of difficulties in the administration. The preparation method is particularly applied in the field of preparation of the enteric targeted particles.

Description

technical field [0001] The invention relates to an enteric-coated targeting granule and a preparation method thereof. Background technique [0002] Tilmicosin is a semi-synthetic macrolide antibiotic for livestock and poultry. It has strong antibacterial activity and a wide antibacterial spectrum. It is effective against all Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, spirochetes , Mycoplasma, etc. have inhibitory effects. The drug has been approved for clinical use in Australia, Brazil, France, Malaysia, Italy, Spain, the United States and other countries for the treatment of infectious diseases in goats, cows, pigs, chickens and other animals. my country has approved tilmicosin drugs for the clinical treatment of livestock and poultry animals. At present, it is mainly administered orally, but tilmicosin tastes bitter, and it will cause anorexia, nausea and vomiting in livestock and poultry during the administration process. Adverse symptoms, result...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/706A61K47/32A61K47/36A61K47/44A61P31/04A61K47/26
Inventor 孙庆申韩德权许永君吴桐
Owner HEILONGJIANG UNIV
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