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Medical gel product for xerostomia and preparation method thereof

A technology for xerostomia and medical supplies, which is applied in the field of xerostomia gel medical supplies and its preparation, can solve problems such as lack of medical efficacy, expensive medicines and side effects, and impossibility of taking medicines for a long time, so as to assist the natural healing mechanism, Good broad-spectrum antiviral activity and the effect of promoting wound healing

Active Publication Date: 2012-07-04
武汉耦合医学科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, medicines are expensive and have great side effects, and for patients with chronic diseases (such as diabetes) with dry mouth, medicines cannot be taken for a long time
At the same time, although there are a variety of saliva substitutes on the market to relieve oral symptoms, artificial saliva, oral moisturizers and lubricants only have moisturizing functions and have no other medical effects; while the imported Bioxtra series products only have imported cosmetics certificates. Cosmetics belonging to the brand name do not have medical effects; doctors are unwilling to recommend them to patients, and if they recommend them, patients do not buy them because they are only imported cosmetics.

Method used

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  • Medical gel product for xerostomia and preparation method thereof
  • Medical gel product for xerostomia and preparation method thereof
  • Medical gel product for xerostomia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] One. preparation gross weight is the xerostomia gel medical supplies of 1000 grams:

[0037] a), weigh 3g of cross-linked polyacrylic acid resin and dissolve it in 200g of pure water, let it stand for 12 hours after completely dissolving, and obtain a water-soluble polymer gel material solution;

[0038] b), take by weighing 1g carboxymethyl chitosan and dissolve in 100 grams of pure water to obtain carboxymethyl chitosan solution;

[0039] c), take by weighing 1g lactoferrin, 0.1g immunoglobulin, 10g sorbitol and 10g bovine colostrum extract respectively, dissolve in 200 grams of pure water, obtain corresponding solution after dissolving;

[0040] d), take by weighing 1g lysozyme and 0.1g lactoperoxidase respectively, be dissolved in 100 grams of purified water to obtain enzyme solution;

[0041] e), mixing the solution prepared in steps b) and c) into the water-soluble polymer gel material solution, adding the remaining 312.8g of pure water, stirring evenly and vacuu...

Embodiment 2

[0058] One. preparation gross weight is the xerostomia gel medical supplies of 1000 grams:

[0059] a), weigh 15g of cross-linked polyacrylic acid resin and dissolve it in 200g of pure water, let it stand for 24 hours after dissolving completely, and obtain a water-soluble polymer gel material solution;

[0060] b), take by weighing 10g hydroxyethyl chitosan and dissolve in 100 grams of purified water to obtain a hydroxyethyl chitosan solution;

[0061] c), take by weighing 2g lactoferrin, 0.2g immunoglobulin, 50g maltitol and 20g bovine colostrum extract respectively, be dissolved in 200 grams of pure water, obtain corresponding solution after dissolving;

[0062] d), take by weighing 2g lysozyme and 0.2g lactoperoxidase respectively, be dissolved in 100 grams of purified water to obtain enzyme solution;

[0063] e), mixing the solution prepared in steps b) and c) into the water-soluble polymer gel material solution, adding the remaining 145.6g of pure water, stirring evenly...

Embodiment 3

[0079] One. preparation gross weight is the xerostomia gel medical supplies of 1000 grams:

[0080] a), weigh 3g of cross-linked polyacrylic acid resin and 2g of hydroxyethyl cellulose and dissolve in 200g of pure water, completely dissolve and let stand for 15 hours to obtain a water-soluble polymer gel material solution;

[0081] b), take by weighing 50g hydroxypropyl chitosan and dissolve it in 100 grams of pure water to obtain a hydroxypropyl chitosan solution;

[0082] c), take by weighing 10g lactoferrin, 1g immunoglobulin, 100g xylitol and 100g bovine colostrum extract respectively, dissolve in 200 grams of pure water, obtain corresponding solution after dissolving;

[0083] d), take by weighing 5g lysozyme and 5g lactoperoxidase respectively, be dissolved in 100 grams of purified water to obtain enzyme solution;

[0084] e), mixing the solution prepared in steps b) and c) into the water-soluble polymer gel material solution, adding the remaining 4g of pure water, stir...

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Abstract

The invention relates to a medical gel product for xerostomia and a preparation method thereof. The medical gel product for xerostomia comprises the following components: 0.1-5% of water-soluble chitosan, 0.3-1.5% of water-soluble polymer gel material, 1-10% of gel viscosity regulator, 0.1-1% of lactoferrin, 0.01-0.5% of lactoperoxidase, 0.1-0.5% of lysozyme, 0.01-0.1% of immunoglobulin, 1-10% ofbovine colostrum extract, 1-10% of anti-caries sweetener, 0.1-1% of neutralizer and the balance of purified water. The preparation method is characterized by firstly mixing the components, subpackaging and then sterilizing with ethylene oxide to obtain the finished product. The medical gel product for xerostomia has the functions of keeping long-acting moisture in the oral cavity, comforting and freshening the oral cavity, resisting bacteria and viruses, preventing dental plaque, reducing gum inflammation and blooding and oral ulcer, promoting the natural healing process of the oral cavity and preventing oral candidiasis. The medical gel product for xerostomia has the advantages of simple and convenient large-scale production process and no environmental pollution in the production process.

Description

technical field [0001] The invention relates to a xerostomia gel medical product and a preparation method thereof. Background technique [0002] Dry mouth is an objective manifestation, which indicates that the secretion of saliva in the oral cavity decreases or the consumption increases due to various reasons, and a negative balance of saliva secretion and consumption occurs in the oral cavity, causing dry mouth. Xerostomia is the main complaint of dry mouth, which is a symptom of subjective feeling. It is the subjective feeling caused by the objective dry mouth stimulation reaching a certain threshold. The sensation of xerostomia (xerostomia) is not always accompanied by objective dry mouth. With the improvement of people's quality of life and the enhancement of self-care awareness, more and more patients seek medical treatment with xerostomia, accounting for about 10% of the population; among the elderly over 65 years old, more than 30% of patients with xerostomia. [0...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K9/06A61P1/02A61P31/02A61P31/12A61P31/10A61K31/722A61K38/40A61K38/44A61K38/47A61K35/20
Inventor 官培龙黄利苹谭伟
Owner 武汉耦合医学科技有限责任公司
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