Wingedtooth laggera herb naphtha extracts, method for preparing wingedtooth laggera herb naphtha extracts, medicinal compositions and application of wingedtooth laggera herb naphtha extracts or medicinal compositions

A composition and extract technology, applied in its preparation, chronic pharyngitis, lingdan grass oil extract, treatment of acute field, can solve the problems of separation and identification of volatile oil of ling dan grass, and achieve curative effect and safety with guaranteed, purity High, avoids the effect of the first pass effect

Active Publication Date: 2011-06-22
YUNNAN PANLONG YUNHAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the identification of these compounds in the volatile oil is mostly obtained by using the mass spectrum search of the instrument database, and then compared with the standard spectrum analysis, and the components in the volatile oil of Lingdancao have not been separated and identified.

Method used

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  • Wingedtooth laggera herb naphtha extracts, method for preparing wingedtooth laggera herb naphtha extracts, medicinal compositions and application of wingedtooth laggera herb naphtha extracts or medicinal compositions
  • Wingedtooth laggera herb naphtha extracts, method for preparing wingedtooth laggera herb naphtha extracts, medicinal compositions and application of wingedtooth laggera herb naphtha extracts or medicinal compositions
  • Wingedtooth laggera herb naphtha extracts, method for preparing wingedtooth laggera herb naphtha extracts, medicinal compositions and application of wingedtooth laggera herb naphtha extracts or medicinal compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation of embodiment 1 panacea oil extract

[0042] Extract 1:

[0043] The preparation method is as follows: take 1000g of the panacea herb, chop it up, extract the volatile oil by steam distillation, extract for 8 hours, put the oil-water mixture in a separating funnel, let it stand, separate the volatile oil, add 2.0g of anhydrous sodium sulfate , and dried to obtain 3.1 g of the target extract. The total terpenoid content of this extract is 75.0%, the active ingredient 1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-α-methylene-2-naphthalene The contents of acetic acid and β-celignene were 18.0% and 7.0%, respectively.

[0044] The assay method of active ingredient in the panacea oil extract is as follows:

[0045] total terpenes

[0046] Preparation of the reference substance solution Accurately weigh an appropriate amount of β-celignene reference substance, add absolute ethanol to make a solution containing 0.15mg β-celignene per 1ml, and obtain the solutio...

Embodiment 2

[0066] Embodiment 2: Prescription and preparation of panacea oil spray

[0067] This example provides a typical implementation of the formulation and preparation method of the panacea oil spray of the present invention.

[0068] Preparation prescription:

[0069] Panacea oil (prepared in Example 1) 10g

[0070] Polysorbate 80 25g

[0071] Poloxamer 188 2.5g

[0072] Macrogol-12 hydroxystearate 20g

[0073] Ethanol 20g

[0074] Sodium Metabisulfite 2g

[0075] Potassium sorbate 2.5g

[0076] Aspartame 1g

[0077] Apple flavor 2ml

[0078] Menthol 0.2g

[0079]

[0080] Add water to make 1000ml

[0081] Preparation method: Take poloxamer 188, polyethylene glycol-12 hydroxystearate, ethanol, mix, heat in a water bath at 60°C to dissolve, take it out, add polysorbate 80, stir well; add panacea oil, stir well, slowly add to 800ml water, stir while adding, and prepare the solution for later use; take aspartame, sodium metabisulfit...

Embodiment 3

[0082] Embodiment 3: the medicinal effect of panacea oil extract

[0083] This example provides the operation and results of the efficacy test of the panacea oil extract prepared in Example 1.

[0084] 1. Comparison of anti-inflammatory effects of extracts 1, 2 and 3

[0085] 1) Comparison of inhibitory effect on mouse croton oily auricle swelling

[0086] Experimental method: 100 CD-1 (ICR) mice, weighing 20±2g, were randomly divided into 10 groups. Apply 0.05ml of 2% croton oil to the front and rear sides of the right ear of the mouse, and the left ear is a contrast. After causing inflammation, smear the medicine half an hour. The medicine is respectively extract 1, 2 or 3 (concentration is respectively 0.5%, 1% and 2 %) and negative control (physiological saline, namely 0.9% NaCl), each 0.02ml each time, the mice were killed 4 hours after the inflammation, and the two ears were cut off along the baseline of the auricle, and a stainless steel punch with a diameter of 8mm...

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Abstract

The invention provides wingedtooth laggera herb naphtha extracts with a definite curative effect and clear structure, a method for preparing the wingedtooth laggera herb naphtha extracts, medicinal compositions for treating acute and chronic pharyngitis and application of the wingedtooth laggera herb naphtha extracts or the medicinal compositions. When prepared into a spraying agent, the extracts have the prominent advantage of treating respiratory diseases, and active ingredients can directly reach the affected part, so that the first pass effect is avoided, the bioavailability of the extracts is improved, the dosage of the extracts is reduced, and the adverse reactions caused by the extracts are reduced or eliminated.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine. Specifically, the present invention relates to a panacea oil extract, a preparation method thereof, a pharmaceutical composition containing the extract, and the use of the extract and the pharmaceutical composition for treating acute and chronic pharyngitis. Background technique [0002] Acute and chronic pharyngitis is a common frequently-occurring disease, mostly in winter and spring, characterized by sore throat, dry throat, itchy throat, foreign body sensation, and hyperplasia of lymphoid follicles in the throat wall. According to statistics, the prevalence rate of chronic tonsillitis natural population in my country is 2.9%; the total prevalence rate of cough is 10.9%; the incidence rate of acute bronchitis is 1%; the incidence rate of chronic bronchitis is 3.82%. The incidence rate also increases, and the prevalence rate over the age of 50 can reach 10-15%. The inciden...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/12A61K9/20A61K9/48A61K9/02A61K9/00A61P11/04
Inventor 刘绍兴高茗胡玉霞余启荣高柏丽和芳祁春艳李馨宇
Owner YUNNAN PANLONG YUNHAI PHARMA
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