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Target spot and medicine for treating cerebral injury

A drug, selected technology, applied in the target and drug field of brain injury treatment, can solve the problems associated with cerebral hemorrhage and so on

Inactive Publication Date: 2013-06-05
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is only one drug currently available for clinical treatment of ischemic stroke (focal cerebral ischemia): tPA (tissue plasminogen activator), which can only be used in a small number of cases, and risk of cerebral hemorrhage

Method used

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  • Target spot and medicine for treating cerebral injury
  • Target spot and medicine for treating cerebral injury
  • Target spot and medicine for treating cerebral injury

Examples

Experimental program
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specific Embodiment

[0156] 1. Experimental materials and methods

[0157] 1.1 Animal model of cerebral ischemia

[0158] Rats (male SD rats, body weight 250-280 g) or mice (male C57BL6 strain mice, body weight 25-30 g) were anesthetized with 10% chloral hydrate, then the skin of the neck was incised, and the cervical Artery (CCA) and external carotid artery (ECA), ligate at both ends of the ECA and then cut a small opening, insert the tie thread through it, tie the tie thread and blood vessel, release the ligation thread near the CCA end, and push the tie thread into the CCA And push the ICA up until there is a slight resistance. In the experiment, after 2 hours of ischemia in rats and 3 hours in mice, the suture was withdrawn and perfusion was resumed (reperfusion). After reperfusion at different times, the mouse brain was taken out and sliced ​​at intervals of 2 mm (rat) or 1 mm (mice), and then the brain slices were incubated in 2% 2,3,5-triphenyltetrazolium chloride (TTC, in 0.9% saline) t...

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Abstract

The invention discloses the substance used for treating or preventing the ischemic brain injuries or neurodegenerative diseases by sustaining the TRPC6 level of nerve cells. The substance may be calpain inhibitors, reinforcing agents of TRPC6 expression, or NMDA receptor antagonists. The invention also discloses the uses of said substance for manufacturing medicaments for preventing or treating ischemic brain injuries or neurodegenerative diseases.

Description

technical field [0001] This application relates to targets and drugs for the treatment of brain injury. Specifically, the present application relates to a TRPC6 target for treating brain damage, as well as methods and drugs for treating brain damage through the target. Background technique [0002] Neurodegenerative diseases are disease states in which cells and neurons of the brain and spinal cord are lost. The brain and spinal cord are made up of neurons that have different functions, such as controlling movement, processing sensory information, and making decisions. Cells in the brain and spinal cord generally do not regenerate, so excessive damage can be devastating and irreversible. Neurodegenerative diseases are caused by the loss of neurons or their myelin sheath, which worsens over time, leading to dysfunction. Neurodegenerative diseases are phenotypically divided into two groups: those affecting movement, such as cerebellar ataxias, and those affecting memory and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K38/55A61K31/13A61K31/4748A61K38/08
CPCA61K38/16A61K38/08A61K38/10A61P21/00A61P25/00A61P25/14A61P25/16A61P25/28A61P9/10
Inventor 王以政杜婉璐黄隽波
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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