Photogene smell simulation system

Abstract

The invention discloses a simulation system in fields of biology and medical science. In the system, a computer inputs simulation parameters to a control unit by a bus; the control unit controls a light source driving unit to generate output light with a specific mode according to the input parameters; an optical fiber coupling unit couples the output light to an optical fiber probe; the optical fiber probe performs light output and irradiates the light to selected olfactory glomeruli; the olfactory glomeruli are induced to form an olfactory active electric signal under photostimulation; and a recording electrode acquires the olfactory active electric signal and transmits the signal to an operational amplification unit, so that the signal is inputted to the computer by the control unit tobe displayed, stored and processed. In the simulation system, the olfactory glomeruli expressing photosensitive proteins with different types are subjected to the photostimulation in different modes,the electric physiological signal and behavioral expression of the olfactory glomeruli are recorded and analyzed, and the codes and identification of an olfactory system on various kinds of smell stimulation and the law of processing, integration and transfer of the signal in the olfactory system are studied to disclose an operating mechanism of the olfactory system.

Description

technical field [0001] The invention relates to an optical gene odor simulation system, which can be applied to the fields of biology and medicine. Background technique [0002] As one of the five senses, the sense of smell plays the functions of identifying the same kind, finding food, calling the police, and affecting emotions. Compared with visual and auditory research, people's research on olfaction is relatively lagging behind. In 1991, Richard Axel and Linda B. Buch published a paper on cell, pointing out that rodents have 1,000 different types of odor gene families, and proved that an olfactory receptor can specifically bind to a variety of odor molecules, while a Odor molecules may also specifically bind to multiple olfactory receptors. This discovery aroused people's great interest in the sense of smell, which made the study of smell reach an unprecedented climax, and many papers were published afterwards. Because of their pioneering research on the sense of smel...

AI Technical Summary

Problems solved by technology

[0005] The average diameter of the olfactory glomeruli in mice is 50 μm. Usually, the light source used to activate the light-sensitive protein is a wide-field light source such as a high-pressure mercury lamp. This may activate all the olfactory glomeruli, and the activation of a single olfactory glomerulus cannot be achieved, so it cannot be accurate. Study how the olfactory system works

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