Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity

A technology of hematocrit and initial filling, which is applied in the direction of measuring devices, biological tests, and electrochemical variables of materials, and can solve problems such as wrong determination of results, time-consuming, negative impact on accuracy, etc.

Inactive Publication Date: 2011-07-06
LIFESCAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods are considered undesirable at least because they involve undesired sample handling, consume unnecessary time and lead to serious errors in finalizing the results
In addition, the temperature of the environment in which samples are analyzed can also negatively affect the accuracy of analyte concentration determination results

Method used

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  • Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity
  • Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity
  • Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity

Examples

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example 1

[0087] The use of the electrochemical system for measuring the initial fill rate based on the measurement of the current is illustrated by the following example. In the following examples, the system includes a sample analysis device, specifically, a figure 2 The immunosensor 110, the gauge configured for applying a potential and the control unit configured for determining the initial filling rate. Specifically, a potential is applied to the electrodes of the immunosensor 110, the hematocrit level is determined, and then the potential is reversed. The analyte concentration is then determined based on the determined hematocrit level. The hematocrit level is determined from the calculated initial fill rate.

[0088] Various samples were provided for analysis to test the performance of the systems, devices and methods disclosed herein. The sample is a blood sample containing C-reactive protein, so the concentration of the analyte determined is that of C-reactive protein. The...

example 2

[0101] The application of an electrochemical system to measure the initial fill rate based on the measurement of the current is further illustrated by another example. The sample analysis device used in this example was also figure 2 The immunosensor 110, the gauge configured to apply a potential and the control unit configured to determine the initial filling rate. Specifically, a potential is applied to the electrodes of the immunosensor 110, the hematocrit level is determined, and then the potential is reversed. Analyte concentrations are then calculated from the determined hematocrit levels. Similar to the previous examples, multiple samples with different hematocrit levels were used with the system to illustrate the performance of the system. Known levels of hematocrit concentration are about 33.5%, about 41%, about 47.5%, and about 56.5%.

[0102] The sample is introduced into the unheated immunosensor by capillary action. The sample enters the fill chamber and move...

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Abstract

The present invention discloses methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.

Description

technical field [0001] The present disclosure relates to determining the concentration of an analyte in a sample, and more particularly to more accurately determining said concentration based on the initial fill rate of the sample. Background technique [0002] Analyte detection in physiological body fluids, such as blood or blood-derived products, is of increasing importance to today's society. Analyte detection assays can be adapted for a variety of applications, including clinical laboratory testing, home testing, etc., and the results of such tests play an important role in the diagnosis and management of a variety of disease conditions. Analytes of interest include glucose, cholesterol, etc. for diabetes management. With the increasing importance of analyte detection, a variety of analyte detection protocols and devices have been developed for clinical and home use. Some of these devices include electrochemical cells, electrochemical sensors, hemoglobin sensors, antio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/00G01N33/53
CPCG01N33/80G01N27/48G01N27/3274G01N33/49G01N2333/4737G01N27/30G01N15/06G01N33/53G01N27/3272G01N27/3273
Inventor R·C·沙特利耶D·赖拉特L·赖恩里A·M·霍奇斯
Owner LIFESCAN INC
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