Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer

一种电容性耦合、射频装置的技术，应用在治疗、电疗法等方向

Inactive Publication Date: 2011-07-06
ANKESAM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This device is only suitable for use in hospitals

Method used

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  • Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer
  • Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer
  • Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0123] SCID mice bearing human medulloblastoma tumors were treated with the device and electrodes of the present invention.

[0124] Three mice were inoculated symmetrically with two tumors in their femoral regions. One of the tumors was treated and the other tumor was used as an individual control. The tumor was measured using SPECT-CT (MEDISO product), and a single shut was performed, 30 minutes, 15W. The treatment was carried out by LabEHY100 (the product of the applicant of the present invention), 13.56 MHz, without pulse modulation applied.

[0125] This example demonstrates the effect of the invention: the blood perfusion in the treated tumor was higher than in its control tumor. This effect supports any chemotherapy or radiotherapy.

[0126] It is not a treatment to cure tumors, but rather to promote other cancer treatments for cures. What this example demonstrates is not the treatment of the tumor itself by hyperthermia, but simply the increase in blood flow shown....

example 2

[0132] Use the device and electrodes of the present invention to treat nude mice with HT29 tumors, for those with 99m The distribution changes of Tc-labeled cholesterol-enriched phospholipid liposomes were studied.

[0133] If not stated otherwise, the same conditions as in Example 1 were used.

[0134] Tumor location: thigh area.

[0135] Radiopharmaceuticals: yes 99m Tc-labeled cholesterol-enriched phospholipid liposomes (injection dose: 60MBq / 0.15mL iv.)

[0136] The results were measured by a high-tech Single Photon Emission Computed Tomography (SPECT).

[0137] The increased enrichment of the radiopharmaceutical (which is the subject of the present invention) was 46% due to increased hemoperfusion compared to the control ( image 3 ). Drug enrichment in this region was also confirmed experimentally.

example 3

[0139] Hemoperfusion was also increased in healthy beagles by comparing the two femoral areas.

[0140] If not stated otherwise, the same conditions as in Example 1 were used.

[0141] Injection of radiopharmaceutical (400MBq 99mTc-HSA). The measurement was performed by Single Photon Emission Computed Tomography (SPECT). Auxiliary heating treatment is a single treatment, 30 minutes, 30W. Blood perfusion measured in treated tissues of healthy beagle dogs following treatment with the device and electrodes of the present invention was clearly higher than that of untreated controls.

[0142] The results showed a 16.8% increase in blood flow in the treated joints ( Figure 4 ).

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Abstract

The present invention relates to a portable radiofrequency (RF) hyperthermia device having flexible applicator treatment electrodes for electric field capacitive coupled energy transfer, the device being useful for increasing the delivery of a systemically delivered drug at a localised target site. The portable RF device is suitable for use by a patient in their own home and the flexible applicator is a flexible, porous, light and easy to manipulate treatment electrode. The inventive device requires no specialist operator to ensure correct usage.

Description

technical field [0001] The present invention relates to a portable radio frequency (RF) hyperthermia device with flexible applicator therapy electrodes for electric field capacitively coupled energy delivery, which is suitable for enhancing systemic delivery of drugs in Localized delivery to the target site. The portable RF device is suitable for use by the patient in their own home, and the flexible applicator is a flexible, porous, light and easily maneuverable therapy electrode. The device of the present invention can ensure correct use without the need for professional operators. Background technique [0002] Heating is widely used in many fields of medicine and is also used in cosmetic treatments. For example, RF / microwave hyperthermia devices may be used to force energy absorption in tissue to cause damage to unwanted structures and / or to raise the temperature of the target area above normal body temperature. One use of thermotherapy devices is in the treatment of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/32A61N1/40
CPCA61N1/403
Inventor 安德拉斯・萨斯奥利佛・萨斯诺拉・伊卢理
Owner ANKESAM CO LTD
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