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Pharmaceutical composition for treating Alzheimer's disease and preparation method thereof

A technology for Alzheimer's disease and composition, which is applied in the field of pharmaceutical composition for the treatment of Alzheimer's disease and its preparation, and can solve problems such as reduced effectiveness

Inactive Publication Date: 2012-05-09
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since AD ​​requires long-term medication, it is often necessary to increase the dose after using cholinesterase inhibitors for more than 4 weeks to achieve the desired effect
Moreover, this type of drug only improves memory in mild dementia but cannot change the progress of neurodegeneration, and the effectiveness of the drug also depends on the integrity of the presynaptic neuron, so its effectiveness decreases with the aggravation of AD

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1, the weight ratio of raw materials: 10 parts of Rehmannia glutinosa, 6 parts of Cornus officinalis, 3 parts of pinellia, 6 parts of Zhuru, 3 parts of Citrus aurantium, 6 parts of Chinese yam, 6 parts of tangerine peel, 9 parts of poria cocos, 3 parts of roasted licorice , 6 parts of Dilong, 3 parts of Shichangpu, 6 parts of ginkgo, 10 parts of medlar, 6 parts of walnut meat, and 6 parts of mulberry.

Embodiment 2

[0036] Example 2, the weight ratio of raw materials: 30 parts of Rehmannia glutinosa, 12 parts of Cornus officinalis, 10 parts of pinellia, 12 parts of Zhuru, 10 parts of Citrus aurantium, 12 parts of Chinese yam, 12 parts of tangerine peel, 15 parts of Poria cocos, 10 parts of roasted licorice , 15 parts of Dilong, 9 parts of Shichangpu, 12 parts of ginkgo, 30 parts of medlar, 12 parts of walnut meat, and 12 parts of mulberry.

Embodiment 3

[0037] Example 3, the weight ratio of raw materials: 20 parts of Rehmannia glutinosa, 10 parts of Cornus officinalis, 6 parts of pinellia, 10 parts of Zhuru, 6 parts of Citrus aurantium, 10 parts of Chinese yam, 10 parts of tangerine peel, 12 parts of poria cocos, 6 parts of roasted licorice , 12 parts of Dilong, 6 parts of Shichangpu, 10 parts of ginkgo, 20 parts of medlar, 102 parts of walnut meat, and 10 parts of mulberry.

[0038] Chinese medicine of the present invention can be prepared by following method:

[0039] (1) The volatile oils are extracted from dried tangerine peel, citrus aurantium, ginkgo, and walnut meat powders by steam distillation, and collected and mixed for later use;

[0040](2) Mix Rehmannia glutinosa, Cornus officinalis, Pinellia pinellia, Zhuru, Chinese yam, Poria cocos, Zhilicorice, Shichangpu, medlar, earthworm, and mulberry, add 10 times the amount of water, add water to decoct, filter, and combine the filtrate, Stand still to clarify and remov...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating Alzheimer's disease and a preparation method thereof, which aims to solve the problem of treatment on the Alzheimer's disease. The pharmaceutical composition is characterized by being prepared from the following raw medicines in proportioning by weight: prepared rehmannia root, dogwood, tuber pinellia, bamboo shavings, immature bitter orange, Chinese yam, dried orange peel powder, tuckahoe, honey-fried licorice root, earthworm, rhizoma acori graminei, ginkgo, medlar, walnut kernel and mulberry fruit. The preparation method of the pharmaceutical composition comprises the following steps of: extracting volatile oil from the dried orange peel, immature bitter orange, ginkgo and walnut kernel; adding the volatile oil into the other raw materials for decocting; extracting the decoction with alcohol; centrifuging, depositing, creaming at low temperature and spray-drying in primary materials; sieving; evenly mixing; and encapsulating to obtain the pharmaceutical composition. The clinical experiment proves that the pharmaceutical composition disclosed by the invention has the characteristics of good treatment effect and higher safety for treating the Alzheimer's disease, and is worthy of clinical application and popularization.

Description

【Technical field】 [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating Alzheimer's disease and a preparation method thereof. 【Background technique】 [0002] Alzheimer's disease (AD), the so-called senile dementia, is a fatal neurodegenerative disease with progressive development. Regression, and various neuropsychiatric symptoms and behavioral disturbances. Epidemiological studies show that the number of Alzheimer's cases in the United States in 2000 was 4.5 million. For every 5-year increase in age, the percentage of Alzheimer's disease patients will double, that is, the prevalence rate of 60-year-old people is 1%, while the prevalence rate of 85-year-old people is 30%. In my country, there are currently 126 million elderly people over the age of 60, and more than 6 million Alzheimer's disease patients. Its prevention and treatment is becoming more and more important. The 2010 European "Guid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P25/28A61K35/64A61K35/62
Inventor 费萍张守荣邢燕
Owner 费萍