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Application of pentoxifylline to preparing medicaments for preventing or treating functional constipation

A technology of pentoxifylline and functional constipation, which is applied in the field of medicine and can solve problems such as unsatisfactory curative effect, anal incontinence, and large trauma

Active Publication Date: 2011-08-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many treatment methods, the curative effect is not satisfactory
Surgical treatment takes a long time, involves large trauma, and complications such as anal incontinence and recurrence may occur
However, biofeedback treatment often requires long-term and repeated treatment, and the curative effect is uncertain.

Method used

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  • Application of pentoxifylline to preparing medicaments for preventing or treating functional constipation
  • Application of pentoxifylline to preparing medicaments for preventing or treating functional constipation
  • Application of pentoxifylline to preparing medicaments for preventing or treating functional constipation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 suppository

[0034] Pentoxifylline 45g

[0035] Polysorbate 80 5g

[0036] Glycerin 3000g

[0037] Gelatin 900g

[0038] Add purified water to 4500g

[0039] Preparation Process:

[0040] Weigh the prescribed amount of gelatin, add an appropriate amount of purified water to the vessel, let it stand for about 1 hour to make it swell and soften, then add the prescribed amount of glycerin and heat it on a water bath to dissolve the gelatin, continue heating and stirring; take ketone cocoa After mixing the alkali and polysorbate 80, add it to the prepared glycerin gelatin solution. After stirring evenly, pour it into the bolt mold coated with lubricant while it is hot, cool it, cut off the overflowing part of the mold mouth, and demould. Quality inspection, packaging, a total of 100 capsules.

Embodiment 2

[0041] The preparation of embodiment 2 suppositories

[0042] Pentoxifylline 50

[0043] Semi-synthetic fatty acid glycerides 4500g

[0044] Glycerin 400g

[0045] Polysorbate 80 50g

[0046] Preparation Process:

[0047] Take semi-synthetic fatty acid glyceride in a vessel, heat and melt in a water bath, and when the temperature drops to about 50°C, add glycerin and polysorbate 80, stir well, add pentoxifylline, stir well, and inject lubricant after stirring well The plug mold is to the degree that it slightly overflows the die opening, cooled, cut off the overflowed part after solidification, demoulding, quality inspection, packaging, and a total of 100 tablets are made.

Embodiment 3

[0048] The preparation of embodiment 3 suppositories

[0049] Pentoxifylline 50g

[0050] Macrogol 4000 2450g

[0051] Macrogol 1000 2450g

[0052] Glycerin 50g

[0053] Preparation Process:

[0054] Put polyethylene glycol 4000 and polyethylene glycol 1000 in a container, heat and melt in a water bath, and when the temperature drops to about 50°C, add glycerin, stir evenly, add pentoxifylline, stir evenly, and inject lubricated The plug mold of the agent is to the degree that it slightly overflows the die opening, cooled, and after solidification, the overflowing part is cut off, demolded, quality inspected, packaged, and a total of 100 tablets are made.

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Abstract

The invention belongs to the field of medicines and relates to a new application of pentoxifylline, in particular to the application of pentoxifylline to preparing medicaments for preventing or treating functional constipation. Therefore, the invention provides a pentoxifylline-contained pharmaceutical composition for treating functional constipation. Shown by tests, the pentoxifylline has marvelous effects in the aspect of treating the functional constipation.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a new application of pentoxifylline, in particular to the application of pentoxifylline in the preparation of medicines for preventing or treating functional constipation. Background technique [0002] Phosphodiesterase (PDE) has the function of hydrolyzing the intracellular second messenger cyclic adenosine monophosphate (cAMP) or cyclic guanosine monophosphate (cGMP), and degrades intracellular cAMP or cGMP, thereby terminating the biochemical effects transmitted by these second messengers . cAMP and cGMP play an important regulatory role in cellular activities. The adjustment of its concentration is mainly determined by the balance between the synthesis of nucleotide cyclase and the hydrolysis of phosphodiesterase (PDE). PDEs are widely distributed in the human body, and their physiological effects involve many research fields. In recent years, PDE, as a new therapeutic target, has ...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61P1/10
CPCA61K9/284A61K31/522A61K9/0014A61P1/10
Inventor 赵志全姚景春
Owner LUNAN PHARMA GROUP CORPORATION
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