Group of nucleotide sequences for detecting gene mutants of hepatitis B virus (HBV) and use thereof

A nucleotide sequence, nucleotide technology, applied in recombinant DNA technology, microbial determination/inspection, DNA/RNA fragments, etc., can solve the problems of low sensitivity, high cost, low efficiency, etc., to improve detection efficiency, The effect of reducing inspection costs
CN102146486AInactive Publication Date: 2011-08-10
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Publication Date
2011-08-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a group of nucleotide sequences for detecting the gene mutants of HBV, which comprise at least one of the nucleotide sequences from SEQ ID No.1 to SEQ ID No.15. The invention also provides the use of the sequences in detection of the gene mutants of HBV. When the nucleotide sequences are used, 10 common gene mutation loci of HBV can be detected. When used for detecting the gene mutants of the HBV, the nucleotide sequences have the advantages of high throughput, high sensitivity and high specificity, are low in detection cost and have a practical clinic promotion and application value.
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Description

technical field

[0001] The invention belongs to the field of virus gene detection, and in particular relates to a group of nucleotide sequences for detecting HBV gene mutations and applications thereof. Background technique

[0002] Hepatitis B virus (HBV) belongs to the hepadnaviridae family, and its genome is about 3.2kb in length, which is a partially double-stranded circular DNA structure. The HBV genome contains four partially overlapping open reading frames, namely pre-S / S region, pre-C / C region, P region and X region. There may be differences in the gene sequences of different HBV strains in the same patient, but they are highly related genetically. Studies have shown that the virus in each patient is a virus group composed of virus strains with differences in gene sequences. The dominant group and the disadvantaged group are relative and are always in constant change. The replication speed of HBV is very fast. It is estimated that HBV can replicate 10 times per 24 ...

Claims

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