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Preparation and application of kit used for testing content of lipid molecules in human blood sample and diagnosing colorectal adenomas

A technology of samples and kits, applied in the direction of measuring devices, material separation, analysis materials, etc., can solve the problems of increasing the risk of distal colorectal adenoma, and achieve the effect of low cost, high accuracy, and less pain

Inactive Publication Date: 2011-08-10
桑建利
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Problems solved by technology

Diet high in choline may increase risk of distal colorectal adenomas in women, study suggests

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  • Preparation and application of kit used for testing content of lipid molecules in human blood sample and diagnosing colorectal adenomas
  • Preparation and application of kit used for testing content of lipid molecules in human blood sample and diagnosing colorectal adenomas
  • Preparation and application of kit used for testing content of lipid molecules in human blood sample and diagnosing colorectal adenomas

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Embodiment Construction

[0056] In recent years, studies have shown that lysophospholipids in lipid molecules are important cell signal transduction molecules. Lysophospholipid molecules, such as LPA (Lysophosphatidic Acid), S1P (Sphingosine-1-phosphate), LPC (Lysophosphatidylcholine) and SPC (Sphingosylphosphorylcholine), can be produced by cells and secreted extracellularly, and participate in various types of extracellular signaling molecules. Biological activity, therefore known as bioactive lipid molecules. The metabolism of these biologically active lipid molecules is closely related to some biologically active factors such as platelet activating factor. LPA is the most studied bioactive lipid molecule in recent years. LPA is involved in a variety of physiological activities, such as brain development, blood pressure regulation, wound healing, sense of smell, and immune and reproductive system functions. At the same time, LPA is closely related to some diseases, especially its role in the occur...

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Abstract

The invention provides a lipid molecule combination used as a biomarker. The lipid molecule combination is prepared into a kit, human blood is used as the sample, the content of lipid marking molecules selected in the kit is tested and analyzed comprehensively, and the possibility of colorectal adenomas of the tested unit is determined according to the analysis result so that colorectal adenomas is detected early and a patient is diagnosed and treated in time.

Description

technical field [0001] The invention provides a biomarker combination of lipid molecules, which is prepared into a kit, and human blood is used as a sample to determine the possibility of an individual suffering from colorectal adenoma according to the content measurement and comprehensive analysis of lipid marker molecules , for early detection of colorectal adenomas. These lipid molecules include: several subtypes of lysophosphatidylcholine (LPC) (20:0LPC, 22:0LPC, 20:4LPC, which are positioned by the Arabic numerals of unsaturated organic compounds, and the numbers after the colon indicate the position of the double bond ), sphingosine phosphorylcholine (SPC), sphingomyelin (SM703, where 703 refers to the molecular weight of this SM subtype). Background technique [0002] 1. Definitions and concepts: [0003] Colorectal adenoma (CRA) is a benign lesion with cancerous potential and is a type of colorectal polyp. Colorectal polyp is a term for clinical diagnosis, which r...

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Application Information

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IPC IPC(8): G01N30/02G01N30/72
Inventor 桑建利张俊杰徐燕赵克
Owner 桑建利
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