Method for preparing aryl ketone

A technology of aryl ketone and aryl boronic acid, which is applied in the field of catalysis, can solve the problems of complex reaction system, unfavorable practical application, and high price, and achieve the effects of simple post-processing, wide application range, and improved utilization efficiency
CN102153434BActive Publication Date: 2014-01-01铜陵市官作文化有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
铜陵市官作文化有限公司
Publication Date
2014-01-01

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Abstract

The invention relates to the field of catalysis, in particular to a method for preparing aryl ketone through reacting aldehyde with aryl boric acid under the catalysis of a ruthenium catalyst. In the method, an organic phosphide is used as a ligand, potassium phosphate is used as alkali, pinacolone or acetone is used as an additive, toluene or / and water is (are) used as a solvent(s), aldehyde and aryl boric acid which are used as reaction substrates react at 95-100 DEG C for 10-24h in the presence of a ruthenium compound used as a catalyst to prepare aryl ketone, wherein the catalyst is one of [Ru(cymene)Cl2]2, [Ru(CO)3Cl2]2, RuH2(CO)PPh3, Ru2(OAc)4, [Ru(benzene)Cl2]2, Ru(S-BINAP)Cl2 or Ru3(CO)12. In the invention, the used catalyst has relatively low price and low toxicity, thereby reducing the preparation cost and being more environmentally friendly.
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Description

technical field

[0001] The invention relates to the field of catalysis, in particular to a method for preparing aryl ketones by catalyzing aldehydes and aryl boronic acids with a ruthenium catalyst. Background technique

[0002] Aryl ketones are a very important class of organic compounds, which are not only included in a variety of physiologically active natural products, but also widely used in the synthesis of other heterocyclic compounds. As a classic method for preparing aryl ketones, Friedel-Crafts acylation has the disadvantages of large amount of catalyst, harsh reaction conditions, difficult post-treatment, poor regioselectivity, narrow substrate range, and difficult preparation and storage of acid chlorides as reaction reagents. For economic and environmental considerations, it is necessary to find a more economical, green and mild method for preparing aryl ketones. The method of catalytic hydrocarbon activation to prepare aryl ketones can undoubtedly solve some o...

Claims

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