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Bacteriostatic and bactericidal activity of phenylglycine derivative on escherichia coli

A kind of technology of phenylglycine and o-bromophenylglycine, applied in the field of synthesizing phenylglycine derivatives

Inactive Publication Date: 2014-02-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although amino acids have not been systematically studied directly as compounds with antibacterial activity, in a large number of studies, some studies have found that amino acids have different effects on the growth and development of soil-borne disease pathogens in cotton, eggplant and other crops.

Method used

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  • Bacteriostatic and bactericidal activity of phenylglycine derivative on escherichia coli
  • Bacteriostatic and bactericidal activity of phenylglycine derivative on escherichia coli
  • Bacteriostatic and bactericidal activity of phenylglycine derivative on escherichia coli

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The antibacterial activity of p-dimethylaminophenylglycine against Escherichia coli was determined according to the antibacterial compound dissolution method, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of in vitro antibacterial activity described in the summary of the invention.

[0026] The experiment found that the minimum inhibitory concentration (MIC) of p-dimethylaminophenylglycine was 125 mg / L (the concentration of HCl aqueous solution as a solvent was 0.0125 mol / L at this time), and the minimum bactericidal concentration (MBC) was 250 mg / L (The concentration of aqueous HCl as a solvent is 0.025 mol / L at this time), therefore, p-dimethylaminophenylglycine has antibacterial activity against Escherichia coli.

Embodiment 2

[0028] The antibacterial activity of m-methylphenylglycine against Escherichia coli was determined according to the antibacterial compound dissolution method, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antibacterial activity in vitro.

[0029] The experiment found that the minimum inhibitory concentration (MIC) of m-methylphenylglycine was 125 mg / L (the concentration of HCl aqueous solution as a solvent was 0.0125 mol / L at this time), and the minimum bactericidal concentration (MBC) was 500 mg / L (as a solvent The concentration of HCl aqueous solution is 0.05 mol / L at this time), therefore, m-methylphenylglycine has antibacterial activity against Escherichia coli.

Embodiment 3

[0031] The antibacterial activity of m-bromophenylglycine against Escherichia coli was determined according to the antibacterial compound dissolution method, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antibacterial activity in vitro.

[0032] The experiment found that the minimum inhibitory concentration (MIC) of m-bromophenylglycine was 125 mg / L (the concentration of HCl aqueous solution as a solvent was 0.0125 mol / L at this time), and the minimum bactericidal concentration (MBC) was 500 mg / L (the concentration of HCl as a solvent The concentration of HCl aqueous solution is 0.05 mol / L at this time), therefore, m-bromophenylglycine has antibacterial activity against Escherichia coli.

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Abstract

The invention discloses that phenylglycine derivative has bacteriostatic and bactericidal activity on escherichia coli. The phenylglycine derivative involved in the invention includes phenylglycine, p-dimethylaminophenylglycine, m-methylphenylglycine, m-bromine phenylglycine, p-chlorphenylglycine and o-bromine phenylglycine. The minimal inhibitory concentration (MIC) of the phenylglycine derivative on escherichia coli is 62.5-125 mg / L, and the minimal bacterial concentration (MBC) is 125-250 mg / L.

Description

technical field [0001] The invention clarifies the relationship between the chemical structure of the medicine and the biological activity of bacteria by synthesizing chemical medicines, more specifically, synthesizing phenylglycine derivatives, and exploring the antibacterial and bactericidal activities of the phenylglycine derivatives on Escherichia coli. Background technique [0002] Amino acid compounds are safe for humans and the environment, especially some amino acid derivatives have obvious pharmacological effects. Therefore, in recent decades, the research and discovery of amino acid derivatives with pharmacological effects has attracted the attention of many researchers and developers. interest. For example, derivatives of 2,3-dihydroxyquinoxaline-6-sulfonyl amino acid have antibacterial activity against some pathogenic microorganisms, such as Bacillus cereus (B. cereus) and Candida utilis (Candidautilis)[ El-Naggar, J. Serb. Chem. Soc., 1986, 51(9-10): 441--447]....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61P31/04
CPCY02A50/30
Inventor 徐伟亮吴坚
Owner ZHEJIANG UNIV
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