478 results about "Bromobenzenes" patented technology

The invention discloses a Br-COFs material and a preparation method thereof as well as a preparation method of a covalent organic framework material interface film of a lithium metal battery. The preparation method comprises the following steps: dissolving 1, 3, 5-tri (4-aminophenyl) benzene and 2, 5-dibromobenzene-1, 4-dicarboxaldehyde in an organic solvent, dropwise adding acetic acid into the solution, reacting the reaction mixture under stirring, filtering, washing and drying to obtain the covalent organic framework material; and dissolving the obtained Br-COFs material and a PVdF adhesive in an organic solvent to obtain a mixed solution, coating the surface of a copper foil with the mixed solution according to a certain thickness, and forming the Br-COFs artificial interfacial film on the surface of a copper foil electrode after the solvent is volatilized. The preparation method is simple, the preparation process is green and environment-friendly, and the prepared product is high in purity, controllable in structure and high in mechanical strength, can be directly used as an artificial interface film of a lithium metal battery, and shows excellent stability when being used for a Li / Cu battery.

The invention discloses a crown ether functionalized covalent organic framework material as well as a preparation method and application thereof, and the method comprises the following steps: adding a covalent organic framework material, 4-bromobenzo-15-crown-5, potassium carbonate and potassium iodide into an acetone solution for reaction, washing the obtained crude product, performing Soxhlet extraction with tetrahydrofuran for a certain time, and drying to obtain the crown ether functionalized covalent organic framework material. The crown ether functionalized covalent organic framework material is obtained. Compared with a synthesis method of crown ether functionalized COFs in the prior art, the method has the advantages that the crown ether (4-bromobenzo-15-crown-5) can be grafted to the COFs in one step, the Na < + > adsorption capacity and the adsorbent recycling performance are greatly improved, the synthesis method is simple, and synthesis of the crown ether functionalized COFs is greener, more convenient and more economical.

The present invention refers to an antagonist of imidazoline-1 receptor (I1R) for use in the prevention and / or treatment of an autoinflammatory or autoimmune disease in a human subject, selected from the group consisting of (±)-2-endo-amino-3-exo- isopropylbicyclo[2.2.1]heptane (synonym: AGN192403), N-benzylguanidine, 2-(2- Fluoro-5-methylphenyl)-4,5-dihydro-1H-imidazole (synonym: S23757), 2-(2-chloro-4-iodo-phenylamino)-5-methyl-pyrroline (synonym: LNP911), 1-(4, 5-dihydro-1H-imidazol- 2-yl)isoquinoline (synonym: BU98008), 5-[2-bromophenoxy)methyl]-4,5-dihydro-1,3- oxazol-2-amine (synonym: S23515), 6-methylamino-2methylheptene (synonym: isometheptene), and 4-chloro-2,3-dihydro-2-oxo-1,3-benzothiazol-3-ylacetic acid (synonym: benazolin). Also, to the use of Imidazole propionate in the diagnosis of an autoinflammatory or autoimmune disease in a subject, and further to a method of diagnosis of atherosclerosis comprising assessing the level of ImP in a blood sample and determining whether said level is above or below a value of 41nM.

The invention discloses a polyether-ether-ketone polishing brush wire material and a preparation method thereof, and belongs to the technical field of brush wire material preparation. The polyether-ether-ketone polishing brush wire material is prepared from, by weight, 50-70 parts of polyether-ether-ketone, 8-13 parts of a modified flexibilizer, 5-10 parts of a modified stabilizer, 3-6 parts of a light stabilizer, 6-12 parts of a lubricant and 2-5 parts of graphite, the modified flexibilizer is prepared from allyl glycidyl ether, benzyl dimethyl silane, vinyl acetic acid and 4-methoxyphenol, and the modified flexibilizer is prepared from vinyl acetate and 4-methoxyphenol. The modified stabilizer is prepared from pentafluorobenzoic acid, potassium tert-butoxide, 1, 10-phenanthroline, pentafluorobromobenzene, 4-aminophenol and pyromellitic dianhydride. The polyether-ether-ketone polishing brush wire material prepared by the method has excellent toughness, organic solvent resistance and wear resistance.

The invention discloses a reinforced and toughened polypropylene plate and a preparation method thereof, and relates to the technical field of high polymer materials. The reinforced and toughened polypropylene plate prepared by the invention is prepared by the following steps: firstly, copolymerizing butene, long-chain olefin and 2-allyl furan to obtain a toughened elastomer; the preparation method comprises the following steps: respectively reacting brominated long-chain olefin with tri (4-bromophenyl) amine and carbazole to obtain an unsaturated heat stabilizer A and an unsaturated heat stabilizer B; then propylene, an unsaturated heat stabilizer A, an unsaturated heat stabilizer B and N-allylmaleimide are copolymerized to obtain modified polypropylene resin, finally, the modified polypropylene resin, a toughening elastomer, a stabilizer, a lubricant and an antioxidant are subjected to mixing and extrusion molding, and the reinforced and toughened polypropylene plate is obtained. The polypropylene plate prepared by the preparation method disclosed by the invention has the advantages of ageing resistance, tensile property and impact resistance.

The present invention relates to a fluxapyroxad intermediate trifluoronitrobiphenyl synthesis method, and belongs to the technical field of organic synthesis, the method comprises the following steps: Step 1: under nitrogen protection, adding 3, 4, 5-bromotrifluorobenzene, o-nitrophenylboronic acid, a catalyst, a promoter, an alkali and a solvent into a reaction flask, and after addition, carrying out a heat preservation reaction; and Step 2: after the reaction is finished, carrying out phase splitting and organic phase concentration to obtain the 3 ', 4', 5 '-trifluoro-2-nitrobiphenyl. Compared with a traditional synthetic method of the trifluoro-nitrobiphenyl, the synthetic method of the trifluoro-nitrobiphenyl has the advantages that the 3, 4, 5-trifluoro-bromobenzene and the o-nitrophenylboronic acid are directly used as raw materials, the production step of preparing the 3, 4, 5-trifluoro-phenylboronic acid from the 3, 4, 5-trifluoro-bromobenzene through a multi-step reaction is avoided, the yield can be effectively improved, the utilization rate of the raw materials is high, and the method is suitable for industrial production. And the o-nitrophenylboronic acid preparation method is simple, the reaction cost can be effectively reduced, the reaction route is shorter, simpler and more efficient, the reaction conditions are mild, and the method has higher industrial application value.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of metaraminol bitartrate. The preparation method comprises the following steps: reacting benzyloxycarbonyl-L-alanine serving as a raw material with dimethylhydroxylamine hydrochloride, then reacting with 3-benzyloxybromobenzene, then carrying out one-step hydrogenation reaction to obtain m-hydroxylamine, and finally salifying to obtain the metaraminol bitartrate. The method adopts a one-step hydrogenation method to simultaneously realize dual effects of reduction and deprotection, reduces operation steps and material consumption, saves material cost, and reduces generation of reaction wastes; in the preparation process, reaction conditions are mild, safety and reliability are achieved, operation is easy, and the obtained target product is high in yield, good in selectivity and suitable for large-scale production.

The invention belongs to the technical field of electrochromic materials, and provides a red-transparent display electrochromic polymer and a preparation method thereof. The method disclosed by the invention comprises the following steps: carrying out ring formation reaction on N-(2, 5-dibromophenyl)-2-ethylhexyl thioamide, potassium ferricyanide and sodium hydroxide to obtain 4, 7-dibromo-2-(heptane-3-yl) benzothiazole; the preparation method comprises the following steps: carrying out substitution reaction on EDOT, n-butyllithium and tributyltin chloride to obtain EDOT-Sn; the preparation method comprises the following steps: carrying out Stille coupling reaction on 2, 4, 7-dibromo-2-(heptane-3-yl) benzothiazole and EDOT-Sn, and then carrying out electrochemical polymerization reaction to obtain the electrochromic polymer. A pure donor (D) type organic molecule is obtained by the method, a corresponding electrochromic film is prepared by electrochemical polymerization, reversible switching between red and transparency is realized, and the electrochromic film has good cycle stability and high color change response speed.

The invention provides a preparation method of a quinazolinone derivative, which comprises the following step: under the catalysis of an alkali, 2-(2-bromophenyl)-2, 3-dihydroquinazolin-4 (1H)-ketone is subjected to a dehalogenation hydrogenation reaction to obtain the quinazolinone derivative. According to the method, an intermediate is obtained after NH group deprotonation and electron transfer are performed under the action of alkali, proton is obtained from the intermediate, then proton transfer hydrogenation debromination is performed to obtain the quinazolinone derivative, a target product is obtained through light and heat methods, raw material synthesis is simple, the production cost can be effectively reduced, the yield and chemical selectivity can be improved, and the method is suitable for industrial production. The method can be conveniently applied to preparation of quinazolinone derivatives.

The invention discloses a preparation method of alplsutentan and an alplsutentan intermediate, alplsutentan is obtained by taking a compound SM1 as a raw material through a one-step method or a multi-step method, and the multi-step method comprises the following steps: reacting the compound SM1 with a compound SM2 to obtain an intermediate I; reacting the intermediate I with 2-[(5-bromo-2-pyrimidinyl) oxy] ethanol to obtain an intermediate II, or reacting the intermediate I with ethylene glycol to obtain an intermediate I-b, and then reacting with 5-bromo-2-chloropyrimidine or 5-fluoro-2-chloropyrimidine to obtain the intermediate II; and finally, removing a protecting group from the intermediate II to obtain alpoxivan. The one-step method comprises the following steps: when X in a compound SM1 is a fluorine atom, the compound SM1 is 5-(4-bromophenyl)-4, 6-difluoropyrimidine, and the compound SM1 reacts with sulfonamide and 2-[(5-bromo-2-pyrimidinyl) oxy] ethanol to directly obtain alpoxivan. The synthesis route is short, and the reaction conditions are mild.

The invention provides a preparation method of 3-(3-bromine-2-methyl-6-methylsulfonyl phenyl)-4, 5-dihydroisoxazole, and the preparation method comprises the following steps: (1) reacting 2, 3-dimethyl-4-methylsulfonyl bromobenzene with an oximation reagent to obtain a 3-bromine-2-methyl-6-methylsulfonyl benzaldoxime reaction solution; (2) mixing the 3-bromine-2-methyl-6-methylsulfonyl benzaldoxime reaction solution obtained in the step (1) with a chlorination reagent to react, so as to obtain a 3-bromine-2-methyl-6-methylsulfonyl benzaldoxime acyl chloride reaction solution; and (3) carrying out a ring closing reaction on the 3-bromo-2-methyl-6-methylsulfonyl benzoxime acyl chloride reaction solution obtained in the step (2) and ethylene, so as to obtain the 3-(3-bromo-2-methyl-6-methylsulfonyl phenyl)-4, 5-dihydroisoxazole. The preparation method is simple in operation steps, high in yield and suitable for industrial production.

The invention discloses a synthesis process of chiral cyclic ether indole. The synthesis process comprises the following steps: reacting 4-bromobenzaldehyde with malonic acid under the catalysis of piperidine to generate olefin carboxylic acid CHP-1; carrying out condensation reaction to prepare CHP-2; under the catalysis of a copper reagent, carrying out Michael addition reaction to obtain CHP-3; preparing a chiral alcohol intermediate CHP-4 through a reduction reaction; trifluoromethanesulfonic acid is used, and a chiral ether intermediate CHP-5 is prepared through ring closing; reacting with protected hydrazine by using a copper ion catalyst to obtain an intermediate CHP-6; the method comprises the following steps: by taking alcohol as a solvent, adding strong acid, and removing a protecting group of hydrazine to obtain an intermediate CHP-7; and carrying out ring closing by taking lewis acid as a catalyst to obtain an indole product CHP-8. The use of a noble metal catalyst palladium is avoided, and the cost is greatly reduced. The chiral center is directly constructed through a chemical method, and SFC is not needed for resolution, so that the cost is remarkably reduced, and industrial production is successfully realized.

The invention relates to the technical field of chemistry, in particular to a synthesis process of 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride, which comprises the following steps: by taking 4-fluoro-3, 5-dimethylbromobenzene as a raw material and hydrazine hydrate as a hydrazine source, matching with alkali such as potassium hydroxide, sodium hydroxide or potassium phosphate and the like, reacting at the temperature of 60-80 DEG C to obtain the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride. The preparation method comprises the following steps: by taking copper or nickel source catalysts such as cuprous bromide, cuprous iodide, nickel salicylate and the like, N, N-bis (2, 6-dimethylphenyl) oxamide as a ligand, hexadecyl trimethyl ammonium bromide as a stabilizer and a dioxane-water mixed system as a solvent, reacting at 80-110 DEG C under the protection of nitrogen, separating a reaction mixed solution after the reaction is finished, and separating the reaction liquid to obtain the target product. And purifying to obtain a finished product of the 4-fluoro-3, 5-dimethyl phenylhydrazine hydrochloride. Therefore, the problems that the synthesis of the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride is poor in safety, low in production efficiency, poor in environmental friendliness, small in substrate application range and the like are solved.

The invention belongs to the field of medicinal chemistry, and relates to an indole acrylic acid amide derivative as well as a preparation method and application thereof. Functional activity screening of G protein dependent signaling pathways is carried out on all synthesized compounds, and it is found that the new derivatives can be used as allosteric antagonism regulators of beta2-adrenergic receptors. Trans-indole acrylic acid with different substituent groups is used as a raw material, amide coupling is performed to obtain the novel indole acrylic acid amide derivative, and R1 is a hydrogen atom, a halogen atom, a methyl group or a methoxyl group; r2 is any one of phenyl, m-bromophenyl, m-chlorphenyl, m-fluorophenyl, m-cyanophenyl, m-methoxyphenyl, cyclohexyl and piperidyl. A biological activity test result shows that the indole acrylic acid amide derivative disclosed by the invention has relatively good antagonistic activity on beta2AR and can be used for carrying out negative allosteric regulation on the functional activity of isoproterenol.

The invention discloses a method for synthesizing a platinum-based nitrogen-doped graphdiyne catalyst based on an atomic layer deposition technology and application of the platinum-based nitrogen-doped graphdiyne catalyst. Firstly, hexabromobenzene and calcium carbide are subjected to vacuum ball milling, calcination and purification to obtain a graphdiyne carrier, then the graphdiyne carrier and melamine are mixed and calcined to achieve nitrogen doping of the carrier, and then loading of platinum nanoparticles is accurately controlled through an atomic layer deposition technology. According to the method, the characteristics of an atomic layer deposition technology are utilized, deposition parameters and the number of cycles are controlled, uniform distribution and size control of Pt nano-particles on porous graphdiyne are achieved, and a nitrogen-doped graphdiyne carrier and the platinum nano-particles have a synergistic effect. The platinum-based nitrogen-doped graphdiyne catalyst prepared by the invention has the specific surface area of 734.8 m < 2 > g < 1 > and the average pore size of 8.68 nm, and shows excellent electrocatalytic activity and dynamic performance in reaction.

The present invention discloses a covalent organic polymer fluorescent probe, and the preparation method is as follows: 2,7-dibromopyrene and 1,2,3,4,5,6-hexa(4-bromophenyl)benzene are added to an organic solvent to dissolve, a Ni(0) catalyst is added, and the reaction is heated overnight. After the reaction is completed, it is cooled to room temperature, an HCl aqueous solution is added, the resulting precipitate is filtered, and washed with an organic solvent to finally obtain the covalent organic polymer fluorescent probe. The fluorescent probe is synthesized by a nickel-catalyzed Yamamoto reaction, has a significant quenching effect on nitro explosives containing OH groups, can be observed with the naked eye to have a significant color change, has high sensitivity, and has a low detection limit; and has no significant response to nitro explosives containing OH groups. Therefore, this fluorescent probe can be used as a specific fluorescent probe for highly selective detection of nitro explosives containing OH groups.

A preparation method of the covalent organic polymer fluorescent probe comprises the following steps: adding 2, 7-dibromopyrene and 1, 2, 3, 4, 5, 6-hexa (4-bromophenyl) benzene into an organic solvent for dissolving, adding a Ni (0) catalyst, and heating overnight for reaction. And after the reaction is finished, cooling to room temperature, adding an HCl aqueous solution, filtering the generated precipitate, and washing with an organic solvent to finally obtain the covalent organic polymer fluorescent probe. The fluorescent probe is synthesized through a nickel-catalyzed Yamamoto reaction, has an obvious quenching effect on-OH-containing nitro explosives, can observe obvious color change through naked eyes, and is high in sensitivity and low in detection limit; the method has no obvious response to-OH-free nitro explosives. Therefore, the fluorescent probe can be used as a specific fluorescent probe for high-selectivity detection of-OH nitro-containing explosives.

The present invention provides a paroxysmal hemoglobinuria indication drug ipropam key intermediate synthesis method, and relates to the technical field of ipropam, the method comprises: taking p-bromobenzaldehyde as an initial raw material, adopting an S-configuration catalyst to obtain an intermediate 03, carrying out protection group removal on the intermediate 03, carrying out automatic ring closing to obtain an intermediate 04, and carrying out post-treatment to obtain the paroxysmal hemoglobinuria indication drug ipropam key intermediate. Reducing the intermediate 04 with sodium borohydride to obtain a single cis-configuration intermediate 05, then carrying out a chiral flip reaction and hydrolysis to remove p-nitrobenzoic acid, then carrying out an etherification reaction with diethyl sulfate to obtain an intermediate 08, reducing amide of the intermediate 08 with sodium borohydride and boron trifluoride diethyl etherate to obtain an intermediate 09, then carrying out an acetylation reaction to protect amino, and finally carrying out a reaction to obtain the chiral cis-configuration intermediate 03. Cuprous cyanide is subjected to a cyanation reaction and a hydrolytic esterification reaction to obtain the ipropam key intermediate TM. The method is low in raw material price, high in chiral control selectivity, easy in reaction condition control and low in equipment requirement, avoids column chromatography and other operations, and is more suitable for industrial production.

The invention discloses an easily degradable modified agricultural mulching film and a preparation method thereof, and relates to the field of high polymer materials. When the easily degradable modified agricultural mulching film is prepared, oyster shell powder sequentially reacts with 3-bromopropyltrimethoxysilane, 4-methylpyridine, 5-(7-bromobenzo [C] [1, 2, 5] thiadiazole-4-yl) thiophene-2-formaldehyde and 4-(diphenylamine) phenylboronic acid pinacol ester, and functionalized oyster shell powder is prepared; and reacting urea with formaldehyde, reacting with monopotassium phosphate and chitosan, mixing with the functionalized oyster shell powder, performing injection molding, and drying to obtain the easily degradable modified agricultural mulching film. The easily-degradable modified agricultural mulching film prepared by the invention has good mechanical properties and capabilities of resisting bacteria, performing photocatalytic degradation, adjusting the pH value of soil and degrading the soil into fertilizers.

The present invention includes compositions and methods of for treating plants infected with fungal pathogens by contacting an infected plant or plant at risk of infection with a fungicidal composition comprising an fungicide selected from copper compound such as copper octanoate or copper hydroxide, or a triazole fungicide such as myclobutanil, propionazole, tebuconazole or epoxiconazole, an enhancer selected from apyrase inhibitors, e.g., N-(m-tolyl)-[1,1′-biphenyl]-4-sulfonamide, S-heptyl 2-oxo-2H-chromene 3-carbothioate, 3-(N-(4-bromophenyl) sulfamoyl)-N-(3-nitrophenyl)benzamide, or (E)-3-methyl-N-(1-(naphthalen-2-yl) ethylidene)benzohydrazide and, optionally, a phytologically-acceptable inert carrier.

The invention discloses a 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole) benzene functionalized hydrothermal bamboo charcoal adsorption material and a preparation method and application thereof.The preparation method of the adsorption material comprises the steps that bamboo powder, 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole bromine) benzene, azodiisobutyronitrile and a solvent are evenly mixed and then subjected to a hydrothermal reaction, and the 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole bromine) benzene functionalized hydrothermal bamboo charcoal adsorption material is obtained. After the reaction is finished, the 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole) benzene functionalized hydrothermal bamboo charcoal adsorbent is obtained. The prepared adsorbent can effectively adsorb anion pollutants, the highest adsorption capacity of methyl orange at room temperature can reach 605mg / g, the highest adsorption capacity of 2, 4-D Na can reach 338mg / g, and the adsorbent can be recycled and has a good application prospect.

The invention provides a synthesis method of an OLED polycyclic fused thiophene compound, and relates to the technical field of material synthesis, and the synthesis method comprises the following steps: providing and mixing 2-naphthalene sulfonic acid and dichloromethane, dropwise adding an N-bromosuccinimide solution into the mixture under the protection of inert gas, and reacting to obtain an intermediate A; dissolving the intermediate A, then adding sodium hydroxide, 4-bromophenylboronic acid, water and tetrakis (triphenylphosphine) palladium, and reacting to obtain an intermediate B; dissolving the intermediate B, adding sulfonic acid and phosphorus pentoxide, and reacting to obtain an intermediate C; adding the intermediate C into tetrahydrofuran, dissolving, adding lithium aluminum hydride under inert gas, and reacting to obtain a target compound. According to the method, the chemical reaction efficiency of the intermediate C is high, and the yield and LC purity of a target product are relatively high.

The invention relates to the technical field of adsorbent preparation, in particular to an imidazolium salt polymer adsorbent as well as a preparation method and application thereof. The preparation method of the imidazolium salt polymer adsorbent comprises the following steps: mixing a polybromophenyl organic compound, imidazole, alkali and a catalyst, and carrying out nucleophilic substitution reaction under the action of the catalyst and the alkali to obtain a triimidazolyl organic monomer; the preparation method comprises the following steps: dissolving a triimidazolyl organic monomer and 1, 4-di (bromomethyl) benzene in an organic solvent, and carrying out quaternization reaction to obtain the imidazolium salt polymer adsorbent. The imidazolium salt polymer adsorbent prepared by the method disclosed by the invention not only can accurately identify and adsorb Cr2O7 < 2-> and remarkably improve the removal efficiency of Cr2O7 < 2->, but also can keep an efficient working state in a wide pH value range. Meanwhile, the material can be easily separated from wastewater and can be repeatedly used after being subjected to simple regeneration treatment, so that cyclic utilization of resources is realized.

The present invention relates to a process for the preparation of a compound of formula (I), a stereoisomer, a salt, a hydrate or a solvate thereof, (II) comprising the step of sulfinylation of a compound of formula (IV) to produce compound of formula (II); (IV) wherein: R1 and R2 are as defined in the claims, wherein said sulfinylation step is performed in the presence of a solvent selected from the group comprising benzene, toluene, ethylbenzene, xylene, chlorobenzene, bromobenzene, fluorobenzene, anisole, nitrobenzene, tetralin, dichlorobenzene, trimethylbenzene, ethylacetate, propylacetate, butylacetate, propanol, butanol, 2- methyltetrahydrofuran, diethylether, methyltertbutylether, cyclopentyl methyl ether, dichloromethane, tetrachloromethane, pentane, hexane, heptane, cyclohexane, decaline and mixtures thereof.

The invention discloses benzo [4, 5] imidazo [2, 1-a] isoquinoline compounds as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The benzo [4, 5] imidazo [2, 1-a] isoquinoline compound can be used for preparing anti-tumor (human breast cancer) drugs, the structure of the benzo [4, 5] imidazo [2, 1-a] isoquinoline compound is shown in the specification, in the formula, R1 is any one or two of hydrogen, halogen, alkyl, alkoxy, fused ring and aryl; r2 is any one of hydrogen, halogen, alkyl and alkoxy; and R3 is any one or two of hydrogen, halogen, alkyl and alkoxy. The preparation method of the compound comprises the following steps: by taking palladium acetate and norbornene as catalysts, tris (4-chlorphenyl) phosphine and the like as ligands, potassium carbonate and the like as alkali and 1, 4-dioxane as a solvent, carrying out one-pot synthesis on a 1-(2-bromo-1-phenyl vinyl) benzimidazole compound and an iodobenzene compound in an argon atmosphere. Structure of compound: # imgabs0 #

The invention provides ester group functionalized cyclotriveratrum hydrocarbon as well as a preparation method and application thereof, and relates to the technical field of gas chromatographic analys.According to the ester group functionalized cyclotriveratrum hydrocarbon and the preparation method and application thereof, a long alkyl chain and an ester group are introduced to the lower edge of cyclotriveratrum hydrocarbon, so that the property of the cyclotriveratrum hydrocarbon serving as a gas chromatographic stationary phase is improved; by introducing a non-polar alkyl chain and a polar ester group, the melting point of the cyclotriveratrum hydrocarbon can be reduced, the film-forming property and the thermal stability of the cyclotriveratrum hydrocarbon are improved, and the separation performance of the cyclotriveratrum hydrocarbon serving as a stationary phase of a capillary gas chromatographic column on an analyte is improved; the method can effectively separate methyl benzaldehyde isomers, bromobenzaldehyde isomers, nitrobenzaldehyde isomers, diethylbenzene isomers, benzene series, homologues, cis-trans isomers and multi-component complex mixtures.

The invention relates to the technical field of catalytic synthesis, in particular to a chloromethylation catalyst, a preparation method of the chloromethylation catalyst and a method for preparing high-purity ortho-position, meta-position and para-position chloromethyl styrene through the chloromethylation catalyst, and the chloromethylation catalyst is prepared by loading sulfonic acid compounds and (or) pyridine compounds and (or) copper salt on a molecular sieve. The method can improve the localization selectivity of chloromethylation. The method for preparing high-purity ortho-position, meta-position and para-position chloromethyl styrene comprises the following steps of: reacting beta-bromophenylethane, paraformaldehyde and lewis acid in the presence of the chloromethylation catalyst to generate chloromethyl beta-bromophenylethane, and then performing elimination reaction under an alkaline condition to generate a chloromethyl styrene crude product; the high-purity ortho-position, meta-position and para-position chloromethyl styrene is obtained after the crude product is rectified, the brand-new catalyst is adopted in the method, the reaction selectivity is enhanced, the process is simple, and industrial production is facilitated.

The present application discloses a lithium extraction agent and extraction method for lithium mother liquor. The lithium extraction agent includes a solute and an organic solvent, the solute includes at least one of 2,3,7,8-tetraaminophenazine-1,4,6,9-tetraketone and terpyridine, and the organic solvent includes at least one of dichloromethane, chloroform, carbon tetrachloride, bromobenzene, and carbon disulfide. The lithium extraction agent of the present application can be used to extract lithium in a lithium mother liquor with a wide pH range. After entering the lithium extraction agent, the lithium ions are quickly complexed with the solute in the lithium extraction agent to form a solid phase. It is only necessary to stand the extracted mixed solution A for phase separation. Lithium is present in the lithium-containing solid complex of the lower oil phase. The lower oil phase can be filtered to obtain the lithium-containing solid complex, and the residual amount of sodium in the lithium-containing solid complex is small. In addition, the extraction method of the present application can omit the washing and stripping sections of the rear end of the traditional extraction process, greatly shortening the extraction process and saving production costs.

The present invention relates to 7-(4-bromophenyl)-2-oxo-9-(trifluoromethyl)-1,2-dihydro-4- hydroxypyrido[3',2':4,5]thieno[3,2-d]pyrimidin or a pharmaceutically acceptable salt, hydrate or solvate thereof, or a hydrate or solvate of a salt thereof, as well as a pharmaceutical composition comprising the same, for use in treating advanced or metastatic cancer with mutations in homologous recombination genes.

The invention discloses an 8-bromine-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative, and the 8-bromine-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative is 8-bromine-5-(4-chlorophenethyl)-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole and / or 8-bromine-5-phenethyl-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole. The invention further discloses a preparation method of the 8-bromine-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative. The 8-bromo-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative provided by the invention has the effects of inhibiting rhizoctonia solani and promoting seed germination. The compound provided by the invention not only can be used for preventing and treating rice sheath blight disease through spraying treatment, but also can be used for preventing rice seeds from carrying bacteria in a seed soaking manner, so that the rice sheath blight disease is comprehensively prevented and controlled. Besides, rice seeds are soaked in a compound solution, germination of the rice seeds can be promoted, the root length, growth vigor and fresh weight indexes of the seeds are improved, and the compound has good application prospects and value in prevention and treatment of the rice sheath blight disease.