16-imidazole substitute-3amine substitute-5 alpha androstane derivatives and preparation method and application thereof

Abstract

The invention relates to 16-imidazole substitute-3amine substitute-5 alpha androstane derivatives, which has the structural formula as the description. In the formula, R1 and R2 are defined as the description. The invention provides a preparation method for the compounds. The compounds have obvious anticancer activity and potential of being developed further, and provide a foundation for new medicine screening.

Description

technical field The invention relates to a 16-azole-substituted-3-amine-substituted-5α-androstane derivative with anticancer activity, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique Cancer is a kind of disease that seriously threatens human health. For advanced cancer, there is no clinical method that can guarantee a complete cure. Chemotherapy is currently the main means of clinical treatment of cancer. However, most of the chemotherapy drugs currently used clinically have toxic and side effects such as nausea, vomiting, hair loss, bone marrow suppression, leukopenia, and hormone level disorders in the body. Therefore, the research and development of new anticancer drugs with high activity, high selectivity and low toxicity has become an important topic for domestic and foreign pharmaceutical companies and scientific research institutes. Steroids are a class of compounds containing cyclopentane and polyh...

AI Technical Summary

Problems solved by technology

However, most of the chemotherapy drugs currently used clinically have side effects such as nausea, vomiting, hair loss, bone marrow suppression, leukopenia, and hormone level disturbances in the body.