Composition for constructing animal model of diabetes mellitus type II

Abstract

The invention provides a composition for constructing an animal model of diabetes mellitus type II and application of the composition to preparing feeds or drugs for constructing the animal model of the diabetes mellitus type II, wherein the composition comprises a conjugated linoleic acid mixture of which the weight percentage is more than 0.1% relative to the composition; and the animal model of the diabetes mellitus type II is prepared by feeding the composition to the mouse. Because the conjugated linoleic acid mixture or a single conjugated linoleic acid monomer is adopted as an inducer and the mouse is adopted as the animal protomodel, compared with a traditional chemical drug or diet induced animal model of the diabetes mellitus type II, the composition provided by the invention has the advantages of low price, convenience and easiness for raw material obtaining; and because the model establishing time is 4-6 weeks, the period is short, the formed model is characterized by hyperglycemia, high insulin level and in-vivo insulin resistance, the composition accords with basic characteristics of the diabetes mellitus type II and is an ideal composition for constructing the animal model of the diabetes mellitus type II.

Description

technical field [0001] The invention relates to a composition, in particular to a composition for constructing type II diabetes animal models. Background technique [0002] According to the 2002 nutritional survey of Chinese residents, the prevalence of diabetes among residents aged 18 and over in my country was 2.6%, and the rate of impaired fasting blood glucose was 1.9%. It is estimated that there are more than 20 million people with diabetes in the country, and another nearly 20 million people have impaired fasting blood sugar. The prevalence rate in urban areas is significantly higher than that in rural areas, and in rural areas of type I is significantly higher than that of type IV rural areas. Compared with the 1996 diabetes sample survey data, the prevalence of diabetes over the age of 20 in large cities rose from 4.6% to 6.4%, and in small and medium-sized cities from 3.4% to 3.9%. Type II diabetes is also called adult-onset diabetes, and it mostly occurs after th...

AI Technical Summary

Problems solved by technology

Animals with hereditary type II diabetes are generally expensive, and cannot well reflect type II diabetes caused by environmental factors such as unreasonable diet structure in humans. Therefore, most of the commonly used models are chemical drugs or diet-induced type II diabetes models

The chemical drug-induced type II diabetes model requires expensive chemical drugs, difficult to control the dose, and unstable modeling, while the diet-induced type II diabetes model has problems such as long modeling time and small blood sugar increase Therefore, there is an urgent need for a new type II diabetes animal model with low price and good modeling effect in this research field.

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