Telmisartan solid dispersion and preparation method thereof

A technology of solid dispersion and telmisartan, which is applied in the field of medicine, can solve the problems that there are no research reports on telmisartan solid dispersion, and achieve the effect of solving the problem of organic solvent residue and improving the dissolution rate

Inactive Publication Date: 2011-09-14
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In the prior art, there is no research report on telmisartan solid dispersion both at home and abroad

Method used

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  • Telmisartan solid dispersion and preparation method thereof
  • Telmisartan solid dispersion and preparation method thereof
  • Telmisartan solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment one: the preparation of telmisartan solid dispersion

[0034] Put 800mg of telmisartan, 80mg of NaOH and 2400mg of polyethylene glycol 6000 melted in a water bath at 50-60°C in an evaporating dish, add an appropriate amount of distilled water and stir until both telmisartan and the polymer are dissolved in water to form a clear solution , freeze-dry until the sample is completely dry.

Embodiment 2

[0035] Embodiment two: the preparation of telmisartan solid dispersion

[0036]Put 800mg of telmisartan, 80mg of NaOH and 2400mg of polyvinylpyrrolidone K-30 in an evaporating dish, add an appropriate amount of distilled water and stir until both telmisartan and polymer are dissolved in water to form a clear solution, then freeze-dry to the sample Dry completely.

Embodiment 3

[0037] Embodiment three: the preparation of telmisartan solid dispersion

[0038] Put 800mg telmisartan, 80mg NaOH and 2400mg hypromellose in an evaporating dish, add an appropriate amount of distilled water and stir until both telmisartan and polymer are dissolved in water to form a clear solution, freeze-dry until the sample is dry completely.

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Abstract

The invention relates to the technical field of medicines, in particular to a telmisartan solid dispersion as a specific angiotensin II receptor antagonist (ATI type) and a preparation method thereof. The telmisartan solid dispersion comprises medicine telmisartan, a carrier and an alkali matter, and also comprises a surfactant, wherein the carrier is a hydrophilic polymeric carrier, and the mass ratio of the medicine telmisartan to the hydrophilic polymeric carrier to the alkali matter to the surfactant is 1:(1-9):(0.1-0.5):(0.1-0.5). The telmisartan solid dispersion has better dissolution rate during the use, and is convenient for gastrointestinal tract absorption, thereby improving bioavailability.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a solid dispersion of telmisartan, a specific angiotensin II receptor (ATI type) antagonist, and a preparation method thereof. Background technique [0002] Hypertension is the most common type of cardiovascular and cerebrovascular diseases. About 972 million people worldwide suffer from high blood pressure or high blood pressure. Equivalent to 26.4% of the adult population. The prevalence of hypertension among adults in my country has risen to 18.8%. The number of sick people nationwide has reached 160 million. It has become a social problem that cannot be ignored. Angiotensin Ⅱ (Ang II) receptor antagonists are another class of antihypertensive drugs after angiotensin-converting enzyme (ACE) inhibitors. Compared with ACE inhibitors, these drugs directly act on receptors and avoid It overcomes the shortcomings of ACE inhibition, has safe and reliable antihypertensive effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4184A61K47/34A61K47/38A61P9/12A61K47/10A61K47/32
Inventor 曹青日刘妍崔京浩
Owner SUZHOU UNIV
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