Persimmon leaf general flavone sustained-release micropills and preparation method thereof

A technology for slow-release pellets and total flavonoids, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problem of large fluctuations in drug blood concentration, decreased patient compliance with medication, and short maintenance time. and other problems to achieve the effect of avoiding peak and valley phenomenon, non-toxic and side effects, and reducing the number of medication

Inactive Publication Date: 2011-09-14
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current commercially available product, Naoxinqing, is a Chinese patent medicine prepared from the total flavonoids of persimmon leaves. It has been praised for its remarkable curative effect; however, it is still used in the form of a common dosage form, and the dosage is three times a day. , relatively more times of administration, causing a relatively large burden on patients
[0003] The disadvantage of using traditional dosage forms is that the blood drug concentration of the drug fluctuates greatly or the maintenance time in the therapeutic concentration is short. Therefore, in order to achieve the purpose of treatment and reduce toxic and side effects, it is often necessary to take multiple administration methods, which makes the patient's compliance with medication sex decline

Method used

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  • Persimmon leaf general flavone sustained-release micropills and preparation method thereof
  • Persimmon leaf general flavone sustained-release micropills and preparation method thereof
  • Persimmon leaf general flavone sustained-release micropills and preparation method thereof

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preparation example Construction

[0027] Preparation of total flavonoids from persimmon leaves:

[0028] The crude extract of persimmon leaves is obtained after extracting persimmon leaves by alcohol extraction; the crude extract of persimmon leaves is distilled under reduced pressure at 55-70°C, then extracted with ethyl acetate, the organic phase is collected, and then distilled to remove The total flavonoids of persimmon leaves were obtained after organic solvent.

[0029] The mass content of the total flavonoids in the prepared total flavonoids of persimmon leaves is 40-70%.

[0030] Refer to (Wang Lan, Zhao Lin. Response surface analysis method to optimize the extraction process of total flavonoids from persimmon leaves [J]. Anhui Agricultural Sciences, 2011, 39(3): 1370-1373.)

Embodiment 1

[0031] The preparation of embodiment 1 persimmon leaf total flavonoids sustained-release pellets

[0032] The preparation method of persimmon leaf total flavonoid sustained-release pellets comprises the following steps:

[0033] 1) Fully dissolving the total flavonoids of persimmon leaves with a mass concentration of 10% of sodium alginate into an aqueous solution of sodium alginate with a mass concentration of 1%, to obtain a total flavonoids of persimmon leaves-sodium alginate solution;

[0034] 2) dissolving chitosan in 1% aqueous acetic acid solution to prepare an acetic acid solution of chitosan with a mass concentration of 0.5%; then adding a calcium chloride aqueous solution with a mass concentration of 1%, stirring evenly to obtain a mixed solution;

[0035] 3) Add the total flavonoids of persimmon leaves-sodium alginate solution into the mixed solution, in terms of mass ratio, total flavonoids of persimmon leaves: sodium alginate: chitosan: calcium chloride=1: 10: 5: ...

Embodiment 2

[0038] The preparation of embodiment 2 persimmon leaf total flavonoids sustained-release pellets

[0039] The preparation method of persimmon leaf total flavonoid sustained-release pellets comprises the following steps:

[0040] 1) fully dissolving the total flavonoids of persimmon leaves with a mass concentration of 50% of sodium alginate into an aqueous solution of sodium alginate with a mass concentration of 5%, to obtain a total flavonoids of persimmon leaves-sodium alginate solution;

[0041] 2) dissolving chitosan in 0.5% aqueous acetic acid solution to prepare an acetic acid solution of chitosan with a mass concentration of 4%; then adding a calcium chloride aqueous solution with a mass concentration of 1%, stirring evenly to obtain a mixed solution;

[0042] 3) Add the total flavonoids of persimmon leaves-sodium alginate solution into the mixed solution, in terms of mass ratio, total flavonoids of persimmon leaves: sodium alginate: chitosan: calcium chloride=1: 2: 0.5:...

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Abstract

The invention discloses persimmon leaf general flavone sustained-release micropills and a preparation method thereof. The persimmon leaf general flavone sustained-release micropills comprise the following components in percentage by mass: 1 to 25 percent of persimmon leaf general flavone, 10 to 50 percent of sodium alginate, 10 to 40 percent of chitosan, 10 to 50 percent of calcium chloride, 0.5 to 5 percent of acetic acid and the balance of water. The persimmon leaf general flavone sustained-release micropills take the persimmon leaf general flavone as active ingredients and are a novel Chinese medicinal sustained-release preparation. General flavone is used as a release amount index, the accumulative release amount of the general flavone of the persimmon leaf general flavone sustained-release micropills in artificial gastric juice and phosphate buffer saline (PBS) buffer solution is 22.97 percent and 34.93 percent respectively within 0.5 hour, does not exceed 45 percent and does not have a burst effect, and results meet the requirement on sustained-release preparations in Chinese pharmacopoeia (the guiding principle of sustained release, controlled release and delayed release in XIXD of 2010 version).

Description

technical field [0001] The invention belongs to the technical field of preparations of total flavonoids from persimmon leaves, and relates to sustained-release pellets of total flavonoids from persimmon leaves and a preparation method thereof. Background technique [0002] According to the current existing literature, as well as research at home and abroad, the dried and fresh leaves of the dicotyledonous persimmon persimmon leaf preparation, persimmon leaf tea and persimmon leaf extract have antihypertensive, diuretic, bacteriostatic, hemostatic, lipid-lowering, and cancer-inhibiting properties. Physiological activity and health care function in various aspects such as tumor growth; and the total flavonoids of persimmon leaves are its main active ingredients. The current commercially available product, Naoxinqing, is a Chinese patent medicine prepared from the total flavonoids of persimmon leaves. It has been praised for its remarkable curative effect; however, it is still ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61K9/16A61K47/36A61P9/12A61P7/10A61P7/04A61P3/06A61P31/04A61P35/00A61K127/00
Inventor 王兰赵麟杨文娟
Owner SHAANXI UNIV OF SCI & TECH
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