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Selegiline-containing adhesive preparation

A preparation and pressure-sensitive adhesive technology, which is applied in the field of adhesive preparations, can solve problems such as unclear stability effects, and achieve the effect of reducing the amount of impurities and high stability

Inactive Publication Date: 2011-09-21
THE FUJIMOTO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the drug is mixed in the pressure-sensitive adhesive for adhering the formulation, there is a problem of generation of degradation products formed by interaction of various trace components with the drug, etc.
[0005] However, selegiline was not examined in JP-A-11-79979, so the stabilizing effect when applied to selegiline is unclear

Method used

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  • Selegiline-containing adhesive preparation
  • Selegiline-containing adhesive preparation
  • Selegiline-containing adhesive preparation

Examples

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Embodiment

[0069] The present invention is described in detail below with reference to Examples and Comparative Examples, however, these Examples and Comparative Examples do not limit the present invention. In this connection, "parts" and "%" used hereinafter mean "parts by weight" and "% by weight", respectively, unless otherwise specified.

[0070] (Preparation of Acrylic Pressure Sensitive Adhesives)

[0071] Under an inert gas atmosphere, make 72 parts of 2-ethylhexyl acrylate (2-EHA), 25 parts of N-vinyl-2-pyrrolidone, 3 parts of acrylic acid and 0.2 parts of azobisisobutyronitrile at 60 °C Solutions of acrylic pressure sensitive adhesives were prepared by solution polymerization in ethyl acetate.

[0072] (Preparation of Adhesive Preparations Containing Selegiline of Examples 1-6 and Comparative Examples 1-4)

[0073] Each pressure-sensitive adhesive solution was prepared according to the blending ratio shown in Table 3 below, its viscosity was adjusted with isopropyl alcohol, an...

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Abstract

The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (-)-(R)-N,.alpha.-dimethyl-N-2-propynylphenethylamine and / or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive, an antioxidant and a metal hydroxide.

Description

technical field [0001] The present invention relates to an adhesive preparation comprising (-)-(R)-N,α-dimethyl-N-2-propynylphenethylamine (hereinafter referred to as "selegiline) free form") and / or a pharmaceutically acceptable salt of (-)-(R)-N,α-dimethyl-N-2-propynylphenethylamine (hereinafter referred to as "selegiline salt of selegiline", and both the salt and the above-mentioned "free form of selegiline" are collectively referred to as "selegiline"). Background technique [0002] The anti-Parkinson's drug selegiline is known as an inhibitor of monoamine oxidase (MAO), and it is also known that there are different subtypes of MAO, namely, type A (MAO-A) and type B (MAO-B), selegiline Legiline is a selective inhibitor of MAO-B. On the other hand, it is known that selegiline also inhibits MAO-A when it is orally administered in a large amount, and it shows an antidepressant effect. However, since many MAO-A are present in digestive organs, when MAO-A is inhibited by or...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/137A61K47/32A61P1/08A61P25/00A61P25/08A61P25/16A61P25/18A61P25/24A61P25/28A61P27/06A61P39/06
CPCA61K31/137A61K9/7061A61P1/08A61P25/00A61P25/08A61P25/16A61P25/18A61P25/24A61P25/28A61P27/06A61P39/06A61K9/7038A61K31/135
Inventor 西浦英里雨山智中村光史井之阪敬悟堀光彦
Owner THE FUJIMOTO CO LTD
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