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Methods and apparatus for detecting molecular interactions using fet arrays

An array and analyte technology, applied in the direction of measuring devices, biochemical equipment and methods, analytical materials, etc.

Inactive Publication Date: 2011-09-28
LIFE TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these and other efforts remain limited by the relatively large size of the reaction volumes required to prepare templates detectable by these systems, as well as the need for specialized nucleotide analogs, and "readout" nucleotide complex enzymatic or fluorescent methods of sequencing

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  • Methods and apparatus for detecting molecular interactions using fet arrays
  • Methods and apparatus for detecting molecular interactions using fet arrays
  • Methods and apparatus for detecting molecular interactions using fet arrays

Examples

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Embodiment Construction

[0271] Below is a more detailed description of various concepts and their embodiments related to the inventive methods and devices related to large-scale chemFET arrays for analyte detection and / or measurement. It should be appreciated that the various concepts, introduced above and discussed in greater detail below, can be implemented in any of a variety of ways, so the disclosed concepts are not limited to any particular implementation. Examples of specific implementations and applications are provided primarily for explanatory purposes.

[0272] Various inventive embodiments according to the present disclosure relate at least in part to semiconductor-based / microfluidic hybrid systems that combine the power of microelectronics with the biocompatibility of microfluidic systems. In some of the following examples, for explanation purposes, the microelectronics portion of the hybrid system is implemented in CMOS technology. It should be understood, however, that the disclosure ...

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Abstract

Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes.

Description

[0001] related application [0002] This application claims priority to US Provisional Application 61 / 133204, filed June 26, 2008, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure generally relates to inventive methods and devices related to the detection and measurement of one or more analytes. Background technique [0004] Electronic devices and assemblies have found numerous applications in chemistry and biology (and more generally, "life sciences"), especially for detecting and measuring different chemical and biological reactions, and for identifying, detecting and measuring different chemical compounds. One such electronic device is known as an ion sensitive field effect transistor, often denoted ISFET (or pHFET) in the relevant literature. ISFETs are routinely employed primarily in the scientific and research community to facilitate the measurement of the hydrogen ion concentration (commonly denoted "p...

Claims

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Application Information

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IPC IPC(8): G01N27/414C12Q1/68H01L29/786H01L29/06G01N27/416
CPCG01N27/414G01N27/4148G01N27/4145
Inventor 乔纳森·M·罗思伯格
Owner LIFE TECH CORP
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