Methods and apparatus for detecting molecular interactions using fet arrays

Abstract

Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes.

Description

[0001] related application

[0002] This application claims priority to US Provisional Application 61 / 133204, filed June 26, 2008, the entire contents of which are incorporated herein by reference. technical field

[0003] The present disclosure generally relates to inventive methods and devices related to the detection and measurement of one or more analytes. Background technique

[0004] Electronic devices and assemblies have found numerous applications in chemistry and biology (and more generally, "life sciences"), especially for detecting and measuring different chemical and biological reactions, and for identifying, detecting and measuring different chemical compounds. One such electronic device is known as an ion sensitive field effect transistor, often denoted ISFET (or pHFET) in the relevant literature. ISFETs are routinely employed primarily in the scientific and research community to facilitate the measurement of the hydrogen ion concentration (commonly denoted "p...

Images