Dihydrotestosterone composition as spray

A dihydrotestosterone and composition technology, applied in the field of dihydrotestosterone sprays, can solve the problems of dosage forms, dosages, administration routes, treatment schemes without consensus, elevated serum testosterone levels, unfavorable normal testicular development, etc., to achieve transportation And the effect of safe and convenient use, small drug content, and solving the problem of medication compliance

Inactive Publication Date: 2013-01-09
CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some people report that the use of HCG can not only make the penis grow significantly, but also increase the body weight and improve the general condition of those with systemic endocrine dysfunction. Therefore, it is advocated that HCG is the first choice for the treatment of penile dysplasia, but it also has the following disadvantages: ① Some suburethral The testes of cleft children have poor response to HCG stimulation, especially those younger than 2 years old are more common, so some cases may not be effective; ②The serum testosterone level can be significantly increased after the use of HCG, which may lead to early development of children with normal development;③ Elevated blood-derived testosterone may produce negative feedback on the hypothalamus-pituitary-testis axis, which is not conducive to the normal development of the testis
Although the clinical application of dihydrotestosterone has been reported, there is no unified opinion on its dosage form, dosage, administration route and treatment plan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Observation of the clinical efficacy of 0.2% dihydrotestosterone spray and human chorionic gonadotropin HCG in the treatment of micropenis

[0017] (1) Cases and methods

[0018] 30 cases of micropenis children with poor development in infancy, prepuberty and puberty.

[0019] Judgment of micropenis: In children with short penis as the main complaint, first exclude cases such as hypospadias, cryptorchidism, webbed penis, hidden penis, buried penis, hermaphroditism and obesity that may affect penis development and size determination. , and then measure the penis length of each case by using the Feldman method [Feldman KW, et al. J Pediatr, 1975; 6(3): 395-398], which is more common at present, and compare it with the commonly used normal penis length reference standard, Those who were less than 2.5 standard deviations from the mean of the same age were included in this study.

[0020] 30 children with micropenis were randomly divided into two groups, 15...

Embodiment 2

[0027] Example 2: Observation on the clinical curative effect of preoperative use of 0.2% dihydrotestosterone spray and 1% testosterone propionate emulsion in children with hypospadias

[0028] (1) Cases and methods

[0029] From May 2009 to April 2010, a total of 28 children with hypospadias were scheduled for elective surgery. For 14 cases in the control group, testosterone propionate emulsion was used before operation (the preparation method of testosterone propionate emulsion is: add 400 mg of testosterone propionate injection for intramuscular injection into 40 g cream base and stir before use), apply locally, 1 time each morning and evening. The 14 cases in the treatment group were treated with dihydrotestosterone spray (preparation method is the same as that in Example 1) before operation, sprayed locally, once a day; after 1 week of withdrawal in each group, the penis length of each case was measured by Feldman method.

[0030] After treatment, if the penis growth ...

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Abstract

The purpose of the present invention is to provide a dihydrotestosterone composition as a spray dosage form, and the application of the dihydrotestosterone composition in the preparation of penis growth preparations before micropenis surgery. The dihydrotestosterone composition as a spray is composed of 0.05% to 0.5% dihydrotestosterone by mass percentage in every 30ml dihydrotestosterone combination, 11-35% volume percentage of penetration enhancer and the balance is 50-70% by volume. % of ethanol water solvent composition. The penetration enhancer is composed of 1-10% menthol and 10-20% propylene glycol, or 1-5% laurocapram, 1-10% menthol and 10-20% propylene glycol by volume percentage. The spray is simple to make, low in cost, non-irritating to the skin, and contains less medicine. It is mainly used for hypospadias surgery or other operations that need to increase the penis in a short time before the operation.

Description

technical field [0001] The invention relates to a dihydrotestosterone spray for treating micropenis, which is mainly used for short-term growth of micropenis before hypospadias operation or other operations. Background technique [0002] Causes of micropenis: Micropenis refers to a person with a normal appearance but a penis extension length that is less than 2.5 standard deviations from the average penis length of people of the same age or normal development of the same sex. The development of the penis mainly depends on the secretion of testosterone (T) by Leydig cells, which is converted into dihydrotestosterone (DHT) under the action of 5a-reductase 2, and then acts on the androgen receptor to make the penis grow. Human chorionic gonadotropin (HCG) secreted by the placenta in the first 15 weeks of pregnancy stimulates Leydig cells to differentiate and secrete T. After 15 weeks, the fetal hypothalamus and pituitary develop maturely, and then the gonadotropin-releasing ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K31/5685A61P15/00
Inventor 袁拥华谷容李秋吕麟亚贾运涛杜甦林涛罗聪
Owner CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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