Cell-wall-breaking low-temperature extraction method and device with assistance of CO2

A technology that assists cells and extraction methods, and is applied in pharmaceutical formulations, solid solvent extraction, and plant raw materials. It can solve the problems of low extraction rate of active ingredients and slow extraction process, and achieve obvious energy saving, easy cleaning, and low investment.

Inactive Publication Date: 2011-10-12
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of slow extraction process and low extraction rate of active ingredients hindered by the cell wall of traditional Chinese medicine in the production and extraction process of existing traditional Chinese medicines, and provide an effective method for extracting Chinese medicine cells at low temperature by breaking the walls of the traditional Chinese medicine. 2 The difference in solubility of gas under different pressures realizes the low-temperature extraction of traditional Chinese medicine cells

Method used

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  • Cell-wall-breaking low-temperature extraction method and device with assistance of CO2
  • Cell-wall-breaking low-temperature extraction method and device with assistance of CO2

Examples

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Effect test

Embodiment 1

[0030] Eucommia ulmoides leaves are crushed into fine powder (through 80 mesh sieve), divided into 2 parts, add 4 times the amount of water respectively, one part is soaked and extracted in an ordinary extraction tank for 1 hour; the other part is added to the hopper 1 and pumped by the pump 2 Mixing chamber 3, simultaneously by CO 2 Inlet a into high pressure CO 2 Gas, keep the pressure in the mixing chamber 3 at 1MPa, mix for 10min under the spiral shear force, and transport it to the low-pressure tank 5 through the material guide device 8, CO 2 The gas solubility drops rapidly, and a large amount of CO 2 Gas escape ruptures the cell wall of traditional Chinese medicine; the diffused CO 2 Gas is drawn from CO by induced draft fan 7 2 The outlet b is discharged, and the extracted material liquid can be entered into the centrifuge by the B pump 6 from the extracted material liquid outlet c for solid-liquid separation. The extraction rate of chlorogenic acid in ordinary ext...

Embodiment 2

[0032] Crush salvia miltiorrhiza into the finest powder (through a 100-mesh sieve), divide it into 2 parts, add 4 times the amount of 70% respectively, put one part in an ordinary extraction tank for immersion extraction for 1 hour; add the other part into the hopper 1 and pump it with pump 2 into the mixing chamber 3, while the CO 2 Inlet a into high pressure CO 2 gas to keep the pressure in the mixing chamber 3 at 1MPa, and the mixing chamber 3 is ground and mixed for 10 minutes with a colloid mill, and then transported to the low-pressure tank 5 through the material guide device 8, and the CO 2 The gas solubility drops rapidly, and a large amount of CO 2 Gas escape ruptures the cell wall of traditional Chinese medicine; the diffused CO 2 Gas is drawn from CO by induced draft fan 7 2The outlet b is discharged, and the extracted material liquid can be entered into the centrifuge by the B pump 6 from the extracted material liquid outlet c for solid-liquid separation. The e...

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Abstract

The invention relates to a cell-wall-breaking low-temperature extraction method and device with assistance of CO2, and the method comprises the following steps: mixing a traditional Chinese medicinal liquid material with the CO2 gas by virtue of a mechanical force under a certain pressure, instantly releasing the pressure so that the CO2 dissolved in a traditional Chinese medicine cell can be rapidly released to realize the cell-wall-breaking low-temperature extraction. The method comprises the following specific steps: completely moisturizing a traditional Chinese medicine solubilizing agent which is crushed into a certain fineness, pumping into a mixing cavity through a high-pressure pump while introducing the high-pressure CO2 gas, mixing by virtue of the mechanical force, and conveying the medicinal liquid to a low-pressure tank through a material guide device after a certain time, wherein the solubility of the CO2 is rapidly reduced, and a great amount of CO2 dissolved in the solution in the cell is rapidly dissipated to break the cell wall, thereby realizing the low-temperature extraction of the traditional Chinese medicine cell wall breaking. The low-temperature extraction method and device provided by the invention are low in investment, efficient and energy-saving, and capable of effectively preventing the thermo-sensitive component from losing in the process of extraction.

Description

technical field [0001] The present invention relates to a CO 2 Assisted cell wall breaking low-temperature extraction method and device, specifically involving the use of CO 2 The difference in solubility of gas under different pressures realizes the low-temperature extraction of traditional Chinese medicine by breaking the cell wall. Background technique [0002] Extraction of traditional Chinese medicine is a process of "preserving its essence and removing its dross", which is also the key to Chinese medicine pharmacy. At present, the extraction process of traditional Chinese medicine production is generally composed of six interrelated and interlaced stages: infiltration, infiltration, desorption, dissolution, diffusion, and replacement. When the solvent is added to the traditional Chinese medicine, due to penetration and diffusion, the solvent gradually penetrates into the cell through the cell wall and cell membrane, and the solvent dissolves a large amount of soluble...

Claims

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Application Information

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IPC IPC(8): B01D11/02A61K36/00
Inventor 蒋东旭谢友良王德杭赖小平
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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