Supercharge Your Innovation With Domain-Expert AI Agents!

Method for extracting 5-hydroxytrophan from griffonia seeds

A technology of hydroxytryptophan and Ghana seed, applied in the direction of organic chemistry, etc., can solve the problems of solvent residue and low yield of 5-hydroxytryptophan

Inactive Publication Date: 2011-10-19
SICHUAN SANHERB BIOTECH
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problems in the prior art that the yield of 5-hydroxytryptophan extracted from Ghana seeds is low, and there are solvent residues in the product, and to provide a product with a high yield of 5-hydroxytryptophan , the extraction method of 5-hydroxytryptophan without solvent residue in the product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extracting 5-hydroxytrophan from griffonia seeds
  • Method for extracting 5-hydroxytrophan from griffonia seeds
  • Method for extracting 5-hydroxytrophan from griffonia seeds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0044] The method for extracting 5-hydroxytryptophan from Ghana seeds that the present embodiment enumerates comprises the following process steps:

[0045] (1) Ultrasonic extraction: Grizzly seeds were crushed to 10 meshes, ultrasonically extracted twice with pure water at a temperature of about 50°C, and the extraction time was 1 hour each time, and the mass ratio of Ghana seed powder to purified water was 1-10;

[0046] (2) Filtration and separation: Combine the extracts, pass through a 60-mesh filter, and then filter the filtrate with a 0.45 μm ultrafiltration membrane;

[0047] (3) Concentration and crystallization: Concentrate the filtrate obtained after ultrafiltration membrane filtration to 1 / 4 of the original volume with a vacuum concentrator, put the concentrated solution in a crystallization tank and cool it to room temperature, then let it stand at a temperature of 4-10°C 12h crystallization to obtain coarse crystals;

[0048] (4) Recrystallization: Heat and dissolv...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for extracting 5-hydroxytrophan, belonging to the technical field of active ingredient extraction. In the invention, the extracting method comprises the following steps of: crushing griffonia seeds and then ultrasonically extracting the crushed griffonia seeds for 1-4 times by using purified water at 30-70 DEG C, wherein the time of each extraction is 1-4 hours, and the mass ratio of the griffonia seeds to the purified water is 1:(6-10); after an extraction liquor is screened with a filter mesh of 60 meshes, filtering the extraction liquor by using an ultrafiltration membrane of 1-5 microns; after the filter liquor is concentrated, crystallizing and recrystallizing the concentrated filter liquor and separating out crystals by using a centrifugal machine; and drying the crystals in a hot air circulating drying box for 5 hours at 65-70 DEG C so as to obtain the 5-hydroxytrophan product. Through HPLC (High Performance Liquid Chromatography) detection, the purity of the obtained product is more than 99% while the conversion rate of the product is more than 70%. Because various organic solvents are not used in the whole process any more, organic solvent residue does not exist in the product and the product is more green and environment friendly.

Description

technical field [0001] The invention relates to a method for extracting 5-hydroxytryptophan, in particular to a method for extracting 5-hydroxytryptophan from Gardner seeds, and belongs to the technical field of active ingredient extraction. Background technique [0002] 5-hydroxytryptophan (5-hydroxytrophan, 5-HTP for short), chemical name: 5-hydroxy-3-indolyl-α-alanine, molecular weight 220.23, its chemical structure is as follows: [0003] [0004] 5-Hydroxytryptophan is catalyzed by tryptophan hydroxylase, an essential amino acid-tryptophan, which can be converted into 5-hydroxytryptamine (5-HT) by decarboxylation in the body, and then passed through hydroxyindoleoxymethyl Invertase action converts to 5-methoxytryptophan (MTrp). 5-hydroxytryptophan is an important neurotransmitter in the human body. 5-methoxytryptophan is the precursor of melatonin. In addition, 5-hydroxytryptophan can also improve the sensitivity of the food center and can be used as a weight loss d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D209/20
Inventor 蒲尚饶洪汉君蹇凯张勤
Owner SICHUAN SANHERB BIOTECH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com