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Method for extracting and purifying resveratrol from polygonum cuspidatum

A technology of resveratrol and Polygonum cuspidatum, which is applied in the chemical field, can solve the problems of high energy consumption, high equipment cost, and poor filtration, and achieve the effects of good industrialization prospects, reduced production costs, and reduced solvent consumption

Inactive Publication Date: 2012-11-28
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This scheme overcomes the shortcomings of using toxic organic solvents in production engineering, but it has the disadvantages of large amount of water, high pressure of subsequent treatment equipment, and high energy consumption; in addition, the temperature control of the process is too high and the range is too wide, which is easy to cause oxidative decomposition of the product ; Sodium hydroxide is used to extract the alkali, and the viscosity of the extraction solution is relatively large, which can easily lead to poor filtration; the method of directly filtering the precipitation in the aqueous solution to obtain the product will cause a large amount of resveratrol to remain in the water, resulting in a decline in the yield; the process does not consider Inorganic metal ions such as Ca 2+ removal, resulting in excessive ash content of the product
In the reports whose publication numbers are CN1513822A and CN1513823A, it is reported that microwave and supercritical CO 2 To extract the method of resveratrol, these methods equipment cost is high, is difficult for industrialized production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The rhizome of Polygonum cuspidatum is crushed to a 14-mesh sieve to obtain Polygonum cuspidatum powder; 4 parts of 100kg Polygonum cuspidatum powder are weighed and placed in a tank-group dynamic countercurrent extraction equipment. 15kg of ferrous sulfate and 8kg of calcium oxide are added to each, 400kg of 60% concentration is added. The ethanol aqueous solution was stirred and extracted in stages at 40°C. The first solution was 60min, the second solution was 50min, the third solution was 40min, and the fourth solution was 30min. The extract was filtered by a plate and frame filter with a 300 mesh filter cloth specification; the extract was 001× 14.5 Cationic resin at a flow rate of 3BV·h -1 , Desalination under the condition of diameter-to-height ratio of 1:4 to obtain a desalted extract; recover the ethanol from the desalted extract at 40°C and a vacuum of -0.075MPa to obtain a purified extract; adjust the pH of the purified extract to 4.5 with dilute hydrochloric aci...

Embodiment 2

[0027] The rhizome of Polygonum cuspidatum is crushed to a 14-mesh sieve to obtain Polygonum cuspidatum powder; weigh 4 parts of 100kg Polygonum cuspidatum powder and place them in a tank-group dynamic countercurrent extraction equipment. Add 17.5kg of iron sulfate and 9kg of calcium hydroxide, each with a concentration of 500kg 65 % Ethanol aqueous solution, stirred and extracted at 45°C in stages, 62min for the primary solution, 52min for the secondary solution, 42min for the third solution, 32min for the fourth solution, and the extract was filtered by a plate and frame filter with a 400 mesh filter cloth specification; the extract was 001 ×16 cationic resin at flow rate 4BV·h -1 , The diameter-to-height ratio is 1:5.5 to obtain a desalted extract; the desalted extract is recovered at 45℃ and a vacuum of -0.08MPa to obtain a purified extract; the purified extract is filled with CO 2 Adjust the pH of the gas to 5.0 to obtain the acidified extract; the cellulase is 3.2×10 7 U is...

Embodiment 3

[0029] The rhizome of Polygonum cuspidatum is crushed to a 14-mesh sieve to obtain Polygonum cuspidatum powder; 4 parts of 100kg Polygonum cuspidatum powder are weighed and placed in a tank-type dynamic countercurrent extraction equipment. 20kg polyferric sulfate and 10kg calcium hydroxide are added each, 600kg concentration 70 is added. % Ethanol aqueous solution, stirred and extracted in batches at 50℃, 65min for the primary solution, 55min for the secondary solution, 45min for the third solution, 35min for the fourth solution, and the extract was filtered by a plate and frame filter with 500 mesh filter cloth specifications; the extract was 001 ×16 cationic resin at flow rate 5BV·h -1 , Desalting under the condition of diameter-to-height ratio of 1:7 to obtain a desalted extract; recover the ethanol from the desalted extract at 50°C and a vacuum of -0.085MPa to obtain a purified extract; adjust the purified extract with dilute hydrochloric acid to pH 5.5 Obtain acidified extr...

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PUM

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Abstract

The invention discloses a method for extracting and purifying resveratrol from polygonum cuspidatum, ethanol, iron salt and alkali are used as extraction media in the method, a multi-stage dynamic countercurrent extraction technology is adopted, and the steps of desalination, purification, acidification, enzymatic hydrolysis, concentration, impurity removal and the like are sequentially carried out extraction liquid, thereby preparing a resveratrol product. The method has the advantages of simple process, short operation time, low production cost, high extraction efficiency, no organic solvent and easy industrial production.

Description

Technical field [0001] The invention relates to a purification method in the chemical field, in particular to a method for extracting and purifying resveratrol from Polygonum cuspidatum. Background technique [0002] Resveratrol (Res for short) is a natural stilbene polyphenol substance produced in plants and a non-flavonoid polyphenol compound containing stilbene structure. Resveratrol is a type of plant antitoxin with special medical and health care functions and significant effects on human health. It has obvious effects on inhibiting cancer cells, lowering blood lipids, preventing and treating cardiovascular diseases, anti-oxidation, and delaying aging. After paclitaxel, another new green anti-cancer drug is considered to be one of the most promising anti-cancer anti-cancer drugs in contemporary humans. At present, this substance has been widely used in food, medicine and health products and other industries, and the market demand is large. In particular, after this substan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/21C07C37/68
Inventor 张强华石莹莹熊清平李东
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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