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Method for preparing inorganic nano particle/silicon dioxide composite microspheres with core shell structure

A technology of inorganic nanoparticles and core-shell structure, applied in the field of composite materials, to achieve the effect of simple and efficient experiment, simple process, and simplified isolation and purification process

Inactive Publication Date: 2011-11-16
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a simple and efficient method for preparing inorganic nanoparticles/silica composite microspheres with a core-shell structure, focusin

Method used

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  • Method for preparing inorganic nano particle/silicon dioxide composite microspheres with core shell structure
  • Method for preparing inorganic nano particle/silicon dioxide composite microspheres with core shell structure
  • Method for preparing inorganic nano particle/silicon dioxide composite microspheres with core shell structure

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Experimental program
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Embodiment 1

[0024] Step 1: Weigh 2mg of CdSeTe quantum dots with an emission wavelength of 517nm, dissolve the quantum dots in 0.5ml of chloroform, add 10mg of PVP as a stabilizer, and disperse uniformly by ultrasonic;

[0025] Step 2, adding the reactant of step 1 into 10ml of ethanol, stirring until the system is uniform;

[0026] Step 3, add 30 μl tetraethyl orthosilicate (TEOS) and 15 μl ammonia water to the reaction system of step 2, stir at a speed of 3000r / min, react for 12h, centrifuge and wash to obtain a core-shell structure inorganic nanoparticle / silicon dioxide composite Microspheres.

[0027] figure 1 It is a low-magnification photo of the prepared core-shell structure inorganic nanoparticles / silica composite microspheres, as shown in the figure, the prepared inorganic nanoparticles / silica core-shell structure composite microspheres have uniform particle size, good dispersion, and no Agglomeration phenomenon, the core-shell structure is clear and complete.

Embodiment 2

[0029] Step 1: Weigh 1 mg of CdSe / ZnS quantum dots with an emission wavelength of 564 nm, dissolve the quantum dots in 1 ml of chloroform, add 200 mg of PEI as a stabilizer, and disperse uniformly by ultrasonic;

[0030] In step 2, the reactant in step 1 is added to 10ml of acetonitrile, and stirred until the system is uniform;

[0031] Step 3: Add 10 μl tetraethyl orthosilicate (TEOS) and 10 μl ammonia water to the reaction system in step 2, stir at a speed of 3000 r / min, react for 36 hours, and centrifuge and wash to obtain a core-shell structure inorganic nanoparticle / silicon dioxide composite Microspheres.

[0032] The prepared composite microspheres have uniform particle size, good dispersion, no agglomeration phenomenon, and clear and complete core-shell structure. figure 2 The fluorescence spectrum of the prepared core-shell structure inorganic nanoparticles / silica composite microspheres, such as figure 2 As shown, the fluorescence emission peak shape is good, and t...

Embodiment 3

[0034] Step 1: Weigh 4mg of CdSe quantum dots with an emission wavelength of 650nm, dissolve the quantum dots in 2ml of cyclohexane, add 200mg of PEO as a stabilizer, and disperse uniformly by ultrasonic;

[0035] Step 2, adding the reactant in step 1 to 5ml of acetonitrile and 5ml of ethanol, stirring until the system is uniform;

[0036] Step 3, add 60 μl tetraethyl orthosilicate (TEOS) and 10 μl ammonia water to the reaction system of step 2, stir at a speed of 3000r / min, react for 48h, centrifuge and wash, and obtain a core-shell structure inorganic nanoparticle / silica composite Microspheres.

[0037] The prepared composite microspheres have uniform particle size, good dispersion, no agglomeration phenomenon, and clear and complete core-shell structure.

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Abstract

The invention relates to a method for preparing inorganic nano particle/silicon dioxide composite microspheres with a core shell structure, comprising the following steps of: dispersing inorganic nano particles into a nonpolar organic solvent, and adding hydrophilic macromolecules as a stabilizer; adding a reactant to a polar reaction medium, such as ethanol and the like, and ultrasonically and uniformly stirring, wherein the volume ratio of the nonpolar organic solvent to the polar reaction medium is 1:5-1:20; adding ethyl orthosilicate and ammonia to a reaction system, wherein the mass ratio of the inorganic nano particles to the ethyl orthosilicate is 1:100-1:10, and the volume ratio of the ammonia to the ethyl orthosilicate is1:10-1:1; and preparing the composite microspheres with the average grain diameter of 15-600 nm. The invention has the advantages that a silicon dioxide shell layer can be prepared in a polar organic solvent through the oil-soluble inorganic nano particles, and therefore, not only the formation of the silicon dioxide shell layer is well controlled and promoted, but also a complex isolation and purification process in an experiment process is simplified; and all reactions are carried out in one system, and therefore an experiment is simple and efficient.

Description

technical field [0001] The invention relates to a composite material applicable to the field of biomedicine, in particular to a method for preparing a core-shell structure inorganic nanoparticle / silicon dioxide composite microsphere. Background technique [0002] In the past two decades, a large number of studies have reported that some nanoparticles can be used in biological systems. In particular, superparamagnetic magnetic nanoparticles and quantum dots prepared by high-temperature oil-phase method have attracted the attention of many researchers due to their potential biological application value, and can be widely used in magnetic resonance imaging (MRI), Targeted therapy of drugs, fluorescence imaging and biosensors, etc. Inorganic nanoparticles have achieved rapid development in biological applications. [0003] However, since inorganic nanoparticles contain heavy metal elements, such as cobalt, chromium, manganese, and iron, they all have cytotoxicity, which also l...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 常津刘俊庆宋涛李云红张琼文
Owner TIANJIN UNIV